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Literature summary for 2.4.2.4 extracted from
- Kinetic studies of thymidine phosphorylase from mouse liver (1985), Biochemistry, 24, 6799-6807.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-deoxy-D-ribose | product inhibition | Mus musculus |  |
| thymine | product inhibition; substrate inhibition | Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.019 | - |
phosphate | - |
Mus musculus | |
| 0.141 | - |
thymine | - |
Mus musculus | |
| 0.945 | - |
thymidine | - |
Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate | rapid equilibrium random bi-bi mechanism with an enzyme-phosphate-thymine dead-end complex | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme in some tissues also catalyzes deoxyribonucleosyltransferase reaction of the type catalyzed by EC 2.4.2.6: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1 | Mus musculus | ? | - |
? | |
| thymidine + phosphate | - |
Mus musculus | thymine + 2-deoxy-D-ribose 1-phosphate | - |
r | |
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