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Literature summary for 2.4.2.36 extracted from

  • Lugo, M.R.; Merrill, A.R.
    The father, son and cholix toxin: The third member of the dt group mono-ADP-ribosyltransferase toxin family (2015), Toxins, 7, 2757-2772.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1H-benzo[de]isoquinoline-1,3(2H)-dione
-
Pseudomonas aeruginosa
2-[(5,6-dimethyl-4-oxo-3,4,4a,7a-tetrahydrothieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-(2-hydroxyethyl)acetamide
-
Pseudomonas aeruginosa
8-fluoro-2-[3-(piperidin-1-yl)propanoyl]-1,3,4,5-tetrahydrobenzo[c][1,6]naphthyridin-6(2H)-one
-
Pseudomonas aeruginosa
PJ34
-
Pseudomonas aeruginosa
PJ34
-
Vibrio cholerae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + diphthamide-[translation elongation factor 2] Pseudomonas aeruginosa
-
nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
-
?
NAD+ + diphthamide-[translation elongation factor 2] Vibrio cholerae
-
nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa P11439
-
-
Vibrio cholerae Q5EK40
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + diphthamide-[translation elongation factor 2]
-
Pseudomonas aeruginosa nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
-
?
NAD+ + diphthamide-[translation elongation factor 2]
-
Vibrio cholerae nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
-
?

Synonyms

Synonyms Comment Organism
cholix toxin
-
Vibrio cholerae
chxA
-
Vibrio cholerae
diphthamide-specific ADPRT
-
Pseudomonas aeruginosa
diphthamide-specific ADPRT
-
Vibrio cholerae
ExoA
-
Pseudomonas aeruginosa
exotoxin A
-
Pseudomonas aeruginosa