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Literature summary for 2.4.2.31 extracted from

  • Ernst, K.; Langer, S.; Kaiser, E.; Osseforth, C.; Michaelis, J.; Popoff, M.R.; Schwan, C.; Aktories, K.; Kahlert, V.; Malesevic, M.; Schiene-Fischer, C.; Barth, H.
    Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins (2015), J. Mol. Biol., 427, 1224-1238.
    View publication on PubMed
Search for more literature for 2.4.2.31

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Clostridium perfringens 5829
-
cytosol
-
 Clostridium botulinum 5829
-
cytosol
-
 Clostridioides difficile 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47000
-
 x * 47000, SDS-PAGE Clostridium perfringens
49000
-
 x * 49000, SDS-PAGE Clostridium botulinum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [actin]-L-arginine177 Clostridium perfringens
-
 nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+
-
 ?
NAD+ + [actin]-L-arginine177 Clostridium botulinum
-
 nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+
-
 ?
NAD+ + [actin]-L-arginine177 Clostridioides difficile
-
 nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridioides difficile
-
-
-
Clostridium botulinum
-
-
-
Clostridium perfringens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Clostridium perfringens
-
 Clostridium botulinum
-
 Clostridioides difficile

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information a large isoform of cyclophilin A, the multi-domain enzyme cyclophilin 40 (Cyp40), binds to the enzyme Clostridium perfringens additional information
-
 ?
additional information a large isoform of cyclophilin A, the multi-domain enzyme cyclophilin 40 (Cyp40), binds to the enzyme Clostridioides difficile additional information
-
 ?
additional information a large isoform of cyclophilin A, the multi-domain enzyme cyclophilin 40, binds to the enzyme Clostridium botulinum additional information
-
 ?
NAD+ + [actin]-L-arginine177
-
 Clostridium perfringens nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+
-
 ?
NAD+ + [actin]-L-arginine177
-
 Clostridium botulinum nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+
-
 ?
NAD+ + [actin]-L-arginine177
-
 Clostridioides difficile nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+
-
 ?

Subunits

Subunits Comment Organism
? x * 47000, SDS-PAGE Clostridium perfringens
? x * 49000, SDS-PAGE Clostridium botulinum

Synonyms

Synonyms Comment Organism
C2 toxin
-
 Clostridium botulinum
C2I
-
 Clostridium botulinum
CDT
-
 Clostridioides difficile
iota toxin
-
 Clostridium perfringens

General Information

General Information Comment Organism
physiological function the enzyme ADP-ribosylates G-actin in the cytosol of target cells resulting in depolymerization of F-actin, cell rounding and cell death Clostridium perfringens
physiological function the enzyme ADP-ribosylates G-actin in the cytosol of target cells resulting in depolymerization of F-actin, cell rounding and cell death Clostridium botulinum
physiological function the enzyme ADP-ribosylates G-actin in the cytosol of target cells resulting in depolymerization of F-actin, cell rounding and cell death Clostridioides difficile