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Literature summary for 2.4.2.31 extracted from

  • Kirby, J.M.; Ahern, H.; Roberts, A.K.; Kumar, V.; Freeman, Z.; Acharya, K.R.; Shone, C.C.
    Cwp84, a surface-associated cysteine protease, plays a role in the maturation of the surface layer of Clostridium difficile (2009), J. Biol. Chem., 284, 34666-34673.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Clostridioides difficile
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General Information

General Information Comment Organism
physiological function Peptoclostridium difficile surface layer consists of the high and low molecular weight S-layer proteins, which are formed from the post-translational cleavage of a single precursor, SlpA. Cysteine potease Cwp84 is involved in maturation of SlpA. Inactivation of the Cwp84 results in a bacterial phenotype in which only immature, single chain SlpA comprises the S-layer. The Cwp84 knock-out mutants display significantly different colony morphology compared with the wild-type strain and grow more slowly in liquid medium. The knock-out strain is competent at causing disease with a similar pathology to the wild-type strain. Whereas Cwp84 plays a role in the cleavage of SlpA, it is not an essential virulence factor Clostridioides difficile