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Literature summary for 2.4.2.30 extracted from

  • MacPherson, L.; Tamblyn, L.; Rajendra, S.; Bralha, F.; McPherson, J.; Matthews, J.
    2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation (2013), Nucleic Acids Res., 41, 1604-1621.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
H532A inactive Homo sapiens
I163A the enzyme shows wild type activity Homo sapiens
Y564A inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-aryl hydrocarbon receptor Homo sapiens
-
 nicotinamide + (ADP-D-ribosyl)n+1-aryl hydrocarbon receptor + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7Z3E1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-aryl hydrocarbon receptor
-
 Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-aryl hydrocarbon receptor + H+
-
 ?

Synonyms

Synonyms Comment Organism
2,3,7,8-tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase
-
 Homo sapiens
ARTD14
-
 Homo sapiens
mono-ADP-ribosyltransferase
-
 Homo sapiens
PARP-7
-
 Homo sapiens
TiPARP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is a transcriptional repressor of aryl hydrocarbon receptor Homo sapiens