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Literature summary for 2.4.2.30 extracted from

  • Maresso, A.W.; Deng, Q.; Pereckas, M.S.; Wakim, B.T.; Barbieri, J.T.
    Pseudomonas aeruginosa ExoS ADP-ribosyltransferase inhibits ERM phosphorylation (2007), Cell. Microbiol., 9, 97-105.
    View publication on PubMed
Search for more literature for 2.4.2.30

Activating Compound

Activating Compound Comment Organism Structure
protein 14-3-3 dependent on Pseudomonas aeruginosa

Cloned(Commentary)

Cloned (Comment) Organism
expression of ExoS in HeLa cells leads to a loss of phosphorylation of ERM proteins, overview, expression of wild-type and mutant ExoS in enzyme-deficient strain PA103, co-expression with 14-3-3 Pseudomonas aeruginosa

Protein Variants

Protein Variants Comment Organism
additional information construction of a truncated ExoS mutant DELTA51-72 Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas aeruginosa ExoS is a virulence factor of the pathogen ?
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor Pseudomonas aeruginosa
-
 nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
NAD+ + moesin Pseudomonas aeruginosa ADP-ribosylated-moesin is a poor target for phosphorylation by protein kinase C and Rho kinase, which shows that ADP-ribosylation directly inhibits ERM phosphorylation nicotinamide + (ADP-D-ribosyl)-moesin
-
 ?
NAD+ + Ras GTPase Pseudomonas aeruginosa
-
 nicotinamide + (ADP-D-ribosyl)-Ras GTPase
-
 ?
NAD+ + vimentin Pseudomonas aeruginosa
-
 nicotinamide + (ADP-D-ribosyl)-vimentin
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ExoS is a virulence factor of the pathogen Pseudomonas aeruginosa ?
-
 ?
additional information ExoS is a bifunctional toxin with an N-terminal Rho GTPase activating protein, GAP, domain, and a C-terminal ADP-ribosyltransferase domain which transfers ADP-ribose from NAD onto substrates such as the Ras GTPases and vimentin Pseudomonas aeruginosa ?
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Pseudomonas aeruginosa nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
NAD+ + moesin ADP-ribosylated-moesin is a poor target for phosphorylation by protein kinase C and Rho kinase, which shows that ADP-ribosylation directly inhibits ERM phosphorylation Pseudomonas aeruginosa nicotinamide + (ADP-D-ribosyl)-moesin
-
 ?
NAD+ + moesin modification of Arg553, Arg560 and Arg563, activity with wild-type and mutant moesins, overview Pseudomonas aeruginosa nicotinamide + (ADP-D-ribosyl)-moesin
-
 ?
NAD+ + Ras GTPase
-
 Pseudomonas aeruginosa nicotinamide + (ADP-D-ribosyl)-Ras GTPase
-
 ?
NAD+ + vimentin
-
 Pseudomonas aeruginosa nicotinamide + (ADP-D-ribosyl)-vimentin
-
 ?

Subunits

Subunits Comment Organism
More the N-terminus with amino acids 96–219 encodes a Rho GTPase activating protein domain, the C-terminus with amino acids 234–453 encodes a 14-3-3-dependent ADP-ribosyltransferase domain Pseudomonas aeruginosa

Synonyms

Synonyms Comment Organism
ADP-ribosyltransferase
-
 Pseudomonas aeruginosa
ExoS
-
 Pseudomonas aeruginosa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Pseudomonas aeruginosa