Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.30 extracted from

  • Aguilar-Quesada, R.; Munoz-Gamez, J.A.; Martin-Oliva, D.; Peralta, A.; Valenzuela, M.T.; Matinez-Romero, R.; Quiles-Perez, R.; Menissier-de Murcia, J.; de Murcia, G.; de Almodovar, M.R.; Oliver, F.J.
    Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition (2007), BMC Mol. Biol., 8, 29.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.30

Protein Variants

Protein Variants Comment Organism
additional information construction of parp-1-knockout mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
3-aminobenzamide
-
 Mus musculus
AG14361
-
 Mus musculus
additional information PARP inhibitors promote ATM activation through induction of double strand breaks Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information subcellular distribution, overview Mus musculus
-
-
nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus PARP-1 responds to DNA damage by transferring 50 to 200 molecules of ADP-ribose to various nuclear proteins, including transcription factors, histones and PARP-1 itself, interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition, ATM and PARP-1 are two of the most important players in the cell's response to DNA damage, PARP-1 is needed for optimal activation of ATM, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NIH-3T3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PARP-1 responds to DNA damage by transferring 50 to 200 molecules of ADP-ribose to various nuclear proteins, including transcription factors, histones and PARP-1 itself, interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition, ATM and PARP-1 are two of the most important players in the cell's response to DNA damage, PARP-1 is needed for optimal activation of ATM, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
PARP-1
-
 Mus musculus
poly(ADP-ribose) polymerase
-
 Mus musculus