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Literature summary for 2.4.2.3 extracted from
- Pyrimidine acyclonucleosides, inhibitors of uridine phosphorylase (1981), Biochem. Pharmacol., 30, 2097-2101.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2'-deoxyglycosylthymine | - |
Homo sapiens |  |
| 2-deoxyglycosylthymine | - |
Homo sapiens | |
| 5-bromoacyclouridine | - |
Homo sapiens | |
| 5-fluoro-2'-deoxyuridine | - |
Homo sapiens | |
| 5-fluoroacyclouridine | - |
Homo sapiens | |
| 5-iodoacyclouridine | - |
Homo sapiens | |
| Acyclothymidine | competitive | Homo sapiens | |
| acyclouridine | competitive | Homo sapiens | |
| Pyrimidine acyclonucleosides | competitive | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.13 | - |
phosphate | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| uridine + phosphate | - |
Homo sapiens | uracil + alpha-D-ribose 1-phosphate | - |
r | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.003 | - |
Acyclothymidine | - |
Homo sapiens | |
| 0.005 | - |
2-deoxyglycosylthymine | - |
Homo sapiens | |
| 0.013 | - |
5-bromoacyclouridine | - |
Homo sapiens | |
| 0.014 | - |
5-fluoroacyclouridine | - |
Homo sapiens | |
| 0.015 | - |
acyclouridine | - |
Homo sapiens | |
| 0.03 | - |
5-iodoacyclouridine | - |
Homo sapiens | |
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