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Literature summary for 2.4.2.28 extracted from

  • Czech, B.; Dettmer, K.; Valletta, D.; Saugspier, M.; Koch, A.; Stevens, A.P.; Thasler, W.E.; Mueller, M.; Oefner, P.J.; Bosserhoff, A.K.; Hellerbrand, C.
    Expression and function of methylthioadenosine phosphorylase in chronic liver disease (2013), PLoS ONE, 8, e80703.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-methyl-5'-thioadenosine + phosphate Homo sapiens
-
adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatic stellate cell high expression in activated hepatic stellate cells Homo sapiens
-
hepatocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-methyl-5'-thioadenosine + phosphate
-
Homo sapiens adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
-
?

Synonyms

Synonyms Comment Organism
methylthioadenosine phosphorylase
-
Homo sapiens
MTAP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is downregulated in chronic liver disease down