Literature summary for 2.4.2.28 extracted from

Parker, W.B.; Allan, P.W.; Ealick, S.E.; Sorscher, E.J.; Hassan, A.E.; Silamkoti, A.V.; Fowler, A.T.; Waud, W.R.; Secrist, J.A.
Design and evaluation of 5-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutant (2005), Nucleosides Nucleotides Nucleic Acids, 24, 387-392.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5'-methylthio-immucillin-adenine	i.e. MT-immucillin-A	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-methyl-5'-thioadenosine + phosphate	Homo sapiens	phosphorolysis	adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Caki-1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
9-[2-deoxy-beta-D-ribofuranosyl]-6-methylpurine + phosphate	a toxic prodrug, 5% of the activity with S-methyl-5'-thioadenosine	Homo sapiens	?	-	?
9-[6-deoxy-beta-L-talofuranosyl]-2-F-adenine + phosphate	a toxic prodrug, 23% of the activity with S-methyl-5'-thioadenosine	Homo sapiens	?	-	?
additional information	9-[6-deoxy-beta-L-talofuranosyl]-6-methylpurine is a poor substrate for the enzyme	Homo sapiens	?	-	?
S-methyl-5'-thioadenosine + phosphate	phosphorolysis	Homo sapiens	adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
5-methylthioadenosine phosphorylase	-	Homo sapiens
MTAP	-	Homo sapiens

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Release 2023.1 (January 2023)