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Literature summary for 2.4.2.28 extracted from

  • Karikari, C.A.; Mullendore, M.; Eshleman, J.R.; Argani, P.; Leoni, L.M.; Chattopadhyay, S.; Hidalgo, M.; Maitra, A.
    Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers (2005), Mol. Cancer Ther., 4, 1860-1866.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene MTAP, located f100 kb telomeric to the p16INK4A/CDKN2A gene on chromosome 9p21, expression in HuCCT1 and SNU308 cell lines, the enzyme expression does not affect the cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knockdown of Mtap protein by RNA interference in L-alanosine-resistant HuCCT1 cells conferred sensitivity to this agent, L-alanosine shows robust growth inhibition in MTAP-negative biliary cancer cell lines CAK-1 and GBD-1 accompanied by striking depletion of intracellular ATP and failure to rescue this depletion via addition of exogenous methylthioadenosine, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens principal enzyme involved in purine synthesis via the salvage pathway, such that MTAP-negative cancers are solely dependent on de novo purine synthesis mechanisms, intracellular Mtap protein levels determine response to purine biosynthesis inhibitor L-alanosine, overview ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
telomeric methylthioadenosine phosphorylase gene MTAP
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Source Tissue

Source Tissue Comment Organism Textmining
biliary duct
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Homo sapiens
-
additional information MTAP expression analysis Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information principal enzyme involved in purine synthesis via the salvage pathway, such that MTAP-negative cancers are solely dependent on de novo purine synthesis mechanisms, intracellular Mtap protein levels determine response to purine biosynthesis inhibitor L-alanosine, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
methylthioadenosine phosphorylase
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Homo sapiens
Mtap protein
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Homo sapiens