Cloned (Comment) | Organism |
---|---|
gene MTAP, located f100 kb telomeric to the p16INK4A/CDKN2A gene on chromosome 9p21, expression in HuCCT1 and SNU308 cell lines, the enzyme expression does not affect the cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of Mtap protein by RNA interference in L-alanosine-resistant HuCCT1 cells conferred sensitivity to this agent, L-alanosine shows robust growth inhibition in MTAP-negative biliary cancer cell lines CAK-1 and GBD-1 accompanied by striking depletion of intracellular ATP and failure to rescue this depletion via addition of exogenous methylthioadenosine, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | principal enzyme involved in purine synthesis via the salvage pathway, such that MTAP-negative cancers are solely dependent on de novo purine synthesis mechanisms, intracellular Mtap protein levels determine response to purine biosynthesis inhibitor L-alanosine, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
telomeric methylthioadenosine phosphorylase gene MTAP | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
biliary duct | - |
Homo sapiens | - |
additional information | MTAP expression analysis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | principal enzyme involved in purine synthesis via the salvage pathway, such that MTAP-negative cancers are solely dependent on de novo purine synthesis mechanisms, intracellular Mtap protein levels determine response to purine biosynthesis inhibitor L-alanosine, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methylthioadenosine phosphorylase | - |
Homo sapiens |
Mtap protein | - |
Homo sapiens |