Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-alpha-D-xylose + [protein]-L-serine | Rumi transfers D-xylose or D-glucose to serine 52 in the O-glucose consensus sequence (50CASSPC55) of factor VII EGF repeat. The second serine (S53) facilitates transfer of Xyl, but not glucose, to the EGF repeat by Rumi. EGF16 of mouse Notch2, which has a diserine motif in the consensus sequence (587CYSSPC592), is also modified with either O-Xyl or O-glucose glycans in cells | Mus musculus | UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine | - |
? | |
UDP-alpha-D-xylose + [protein]-L-serine | Rumi transfers D-xylose or D-glucose to serine 52 in the O-glucose consensus sequence (50CASSPC55) of factor VII EGF repeat. The second serine (S53) facilitates transfer of Xyl, but not glucose, to the EGF repeat by Rumi. EGF16 of mouse Notch2, which has a diserine motif in the consensus sequence (587CYSSPC592), is also modified with either O-Xyl or O-glucose glycans in cells | Homo sapiens | UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Rumi | in addition to protein O-glucosyltransferase activity, both human and mouse Rumi also show protein O-xylosyltransferase activity | Mus musculus |
Rumi | in addition to protein O-glucosyltransferase activity, both human and mouse Rumi also show protein O-xylosyltransferase activity | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Mus musculus |
7 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | XT-I gene expression is down-regulated by IL-1beta | down |
Homo sapiens | XT-I gene expression is down-regulated by IL-1beta | down |
Mus musculus | XT-I gene expression is up-regulated by TGF-beta1 | up |
Homo sapiens | XT-I gene expression is up-regulated by TGF-beta1 | up |