Cloned (Comment) | Organism |
---|---|
expression of full length and C-terminally truncated enzymes in Escherichia coli | Leishmania donovani |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of the glycosomal targeting sequence, a C-terminal tripeptide, leads to mislocation of the enzyme in the cytosol, where the enzyme nevertheless is still active | Leishmania donovani |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
glycosome | deletion of the glycosomal targeting sequence, a C-terminal tripeptide, leads to mislocation of the enzyme in the cytosol, where the enzyme nevertheless is still active | Leishmania donovani | 20015 | - |
additional information | immunohistologic subcellular localization study | Leishmania donovani | - |
- |
peroxisome | deletion of the peroxisomal targeting sequence is not required for activity | Leishmania donovani | 5777 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-phospho-alpha-D-ribose 1-diphosphate + xanthine | Leishmania donovani | the enzyme is involved in purine nucleotide synthesis via phosphorylation of purines acquisited from the host, since Leishmania donovani is not able to perform de novo biosynthesis of purine nucleotides | 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant full length and C-terminally truncated enzymes from Escherichia coli by affinity chromatography | Leishmania donovani |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
promastigote | - |
Leishmania donovani | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-phospho-alpha-D-ribose 1-diphosphate + xanthine | - |
Leishmania donovani | 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate | - |
? | |
5-phospho-alpha-D-ribose 1-diphosphate + xanthine | the enzyme is involved in purine nucleotide synthesis via phosphorylation of purines acquisited from the host, since Leishmania donovani is not able to perform de novo biosynthesis of purine nucleotides | Leishmania donovani | 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
xanthine PRT | - |
Leishmania donovani |
XPRT | - |
Leishmania donovani |