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Literature summary for 2.4.2.19 extracted from

  • Ishidoh, K.; Kamemura, N.; Imagawa, T.; Oda, M.; Sakurai, J.; Katunuma, N.
    Quinolinate phosphoribosyl transferase, a key enzyme in de novo NAD(+) synthesis, suppresses spontaneous cell death by inhibiting overproduction of active-caspase-3 (2010), Biochim. Biophys. Acta, 1803, 527-533.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3)-RIPL Codon Plus Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15274
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-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, dye ligand chromatography (Blue-Sepharose), ion exchange chromatography Homo sapiens

Synonyms

Synonyms Comment Organism
quinolinate phosphoribosyltransferase
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Homo sapiens

General Information

General Information Comment Organism
physiological function interacts with active-caspase-3, depletion of quinolinate phosphoribosyltransferase protein increases intracellular caspase-3 activity, quinolinate phosphoribosyltransferase-depleted cells are highly sensitive to spontaneous cell death, quinolinate phosphoribosyltransferase protein prevents spontaneous cell death through inhibition of overproduction of active-caspase-3, identified as a caspase-3 binding protein, not a substrate for caspase-3 Homo sapiens