Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3)-RIPL Codon Plus | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q15274 | - |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate precipitation, dye ligand chromatography (Blue-Sepharose), ion exchange chromatography | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
quinolinate phosphoribosyltransferase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | interacts with active-caspase-3, depletion of quinolinate phosphoribosyltransferase protein increases intracellular caspase-3 activity, quinolinate phosphoribosyltransferase-depleted cells are highly sensitive to spontaneous cell death, quinolinate phosphoribosyltransferase protein prevents spontaneous cell death through inhibition of overproduction of active-caspase-3, identified as a caspase-3 binding protein, not a substrate for caspase-3 | Homo sapiens |