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Literature summary for 2.4.2.19 extracted from
- Isolation and properties of crystalline quinolinate phosphoribosyltransferase from hog kidney (1980), Biochim. Biophys. Acta, 611, 280-288.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-oxoglutarate | 1 mM, 55% inhibition | Sus scrofa |  |
| acetic acid | 26% inhibition | Sus scrofa | |
| aspartic acid | 1 mM, 37% inhibition | Sus scrofa | |
| Citric acid | 1 mM, 89% inhibition | Sus scrofa | |
| formic acid | 1 mM, 54% inhibition | Sus scrofa | |
| Fumaric acid | 1 mM, 67% inhibition | Sus scrofa | |
| L-Glutamic acid | 1 mM, 41% inhibition | Sus scrofa | |
| L-Malic acid | 1 mM, 67% inhibition | Sus scrofa | |
| Lactic acid | 1 mM, 29% inhibition | Sus scrofa | |
| Maleic acid | 1 mM, 42% inhibition | Sus scrofa | |
| oxaloacetic acid | 1 mM, 59% inhibition | Sus scrofa | |
| succinic acid | 1 mM, 46% inhibition | Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
quinolinate | - |
Sus scrofa | |
| 0.14 | - |
5-phospho-alpha-D-ribose 1-diphosphate | - |
Sus scrofa | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | absolute requirement for divalent cations. Mg2+ is most effective. Optimal concentrations are 4, 6 and 10 mM for 20, 40 and 100 mM sodium acetate/acetic acid buffer, pH 5.5 | Sus scrofa | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | enzyme contains 1% mannose | Sus scrofa |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.091 | - |
- |
Sus scrofa |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 0-4°C, crystalline enzyme is stable for at least 2 years | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Sus scrofa | nicotinate D-ribonucleotide + diphosphate + CO2 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
- |
Sus scrofa |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 3 | 3.5 | 37°C, denatured abruptly | Sus scrofa |
| 4.5 | 9.5 | 37°C, 30 min, completely stable | Sus scrofa |
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