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Literature summary for 2.4.2.18 extracted from

  • Evans, G.L.; Furkert, D.P.; Abermil, N.; Kundu, P.; de Lange, K.M.; Parker, E.J.; Brimble, M.A.; Baker, E.N.; Lott, J.S.
    Datasets, processing and refinement details for Mtb-AnPRT inhibitor structures with various space groups (2017), Data Brief, 15, 1019-1029 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.18

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitors, hanging drop vapor diffusion method, using 0.2 M imidazole. malate, pH 7.0, 15% (w/v) PEG 4000 Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
2-(2-carboxyphenylamino)-5-(3-phosphonopropoxy)benzoic acid
-
 Mycobacterium tuberculosis
2-(2-carboxyphenylamino)-5-(4-phosphonobutoxy)benzoic acid
-
 Mycobacterium tuberculosis
2-(2-carboxyphenylamino)-5-(5-phosphonopentyloxy)benzoic acid
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Mycobacterium tuberculosis
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 r
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate Mycobacterium tuberculosis
-
 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis A5U4M0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Mycobacterium tuberculosis N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 r
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 Mycobacterium tuberculosis anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r

Synonyms

Synonyms Comment Organism
AnPRT
-
 Mycobacterium tuberculosis