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Literature summary for 2.4.2.18 extracted from

  • Cookson, T.V.; Evans, G.L.; Castell, A.; Baker, E.N.; Lott, J.S.; Parker, E.J.
    Structures of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase variants reveal the conformational changes that facilitate delivery of the substrate to the active site (2015), Biochemistry, 54, 6082-6092.
    View publication on PubMed
Search for more literature for 2.4.2.18

Crystallization (Commentary)

Crystallization (Comment) Organism
mutant enzymes N138A, P180A, R193L, R193A, R194A, and G107P, hanging drop vapor diffusion method, using Mycobacterium tuberculosis

Protein Variants

Protein Variants Comment Organism
R193L inactive Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
anthranilate substrate inhibition Mycobacterium tuberculosis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate Mycobacterium tuberculosis
-
 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate Mycobacterium tuberculosis H37Rv
-
 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WFX5
-
-
Mycobacterium tuberculosis H37Rv P9WFX5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 Mycobacterium tuberculosis anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 Mycobacterium tuberculosis H37Rv anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AnPRT
-
 Mycobacterium tuberculosis