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Literature summary for 2.4.2.14 extracted from

  • King, G.L.; Boounous, C.G.; Holmes, E.W.
    Human placental amidophosphoribosyltransferase. Comparison of the kinetics of glutamine and ammonia utilization (1978), J. Biol. Chem., 253, 3933-3938.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
6-diazo-5-oxo-L-norleucine competitive vs. glutamine, inactivation half-life: 11 min Homo sapiens
AMP 5 mM, 79% and 24% inhibition of aminotransferase and amidotransferase activity at 1 mM 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
azaserine competitive vs. glutamine, inactivation half-life: 12 min Homo sapiens
GMP 0.5 mM; 5 mM, 56% and 12% inhibition of aminotransferase and amidotransferase activity at 1 mM 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
NH3 inhibition of amidotransferase activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic properties of amido- and aminotransferase activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-cellulose, partial purification Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.001
-
L-glutamine Homo sapiens
0.00297
-
NH3 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O no activity with carbamoyl phosphate Homo sapiens 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate
-
?
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O reaction at 33% the rate of amminotransferase activity Homo sapiens 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate
-
?
NH3 + 5-phospho-alpha-D-ribose 1-diphosphate + H2O 3fold higher aminotransferase activity compared to amidotransferase activity Homo sapiens 5-phospho-beta-D-ribosylamine + diphosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0034
-
6-diazo-5-oxo-L-norleucine
-
Homo sapiens
3.3
-
NH3
-
Homo sapiens
4
-
azaserine
-
Homo sapiens