BRENDA - Enzyme Database
show all sequences of 2.4.2.14

Human glutamine phosphoribosylpyrophosphate amidotransferase. Kinetic and regulatory properties

Holmes, E.W.; McDonald, J.A.; McCord, J.M.; Wyngaarden, J.B.; Kelley, W.N.; J. Biol. Chem. 248, 144-150 (1973)

Data extracted from this reference:

General Stability
General Stability
Organism
Mg2+ and phosphate are essential for stability
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
6-iodopurine
5 mM, 39% inhibition
Homo sapiens
6-mercaptopurine ribonucleotide
5 mM, 64% inhibition
Homo sapiens
ADP
5 mM, 40% inhibition
Homo sapiens
allopurinol ribonucleotide
5 mM, 68% inhibition
Homo sapiens
AMP
5 mM, 76% inhibition, noncompetive vs. glutamine
Homo sapiens
ATP
5 mM, 21% inhibition
Homo sapiens
CMP
5 mM, 22% inhibition
Homo sapiens
dCMP
5 mM, 26% inhibition
Homo sapiens
GDP
5 mM, 40% inhibition
Homo sapiens
GMP
0.5 mM; 5 mM, 70% inhibition
Homo sapiens
GTP
5 mM, 13% inhibition
Homo sapiens
IDP
5 mM, 29% inhibition
Homo sapiens
IMP
5 mM, 41% inhibition
Homo sapiens
methyl-dCMP
5 mM, 47% inhibition
Homo sapiens
OMP
5 mM, 25% inhibition
Homo sapiens
phosphate
competitive vs. 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
TMP
5 mM, 42% inhibition
Homo sapiens
TTP
5 mM, 12% inhibition
Homo sapiens
UDP
5 mM, 19% inhibition
Homo sapiens
UMP
5 mM, 25% inhibition
Homo sapiens
UTP
5 mM, 16% inhibition
Homo sapiens
XDP
5 mM, 27% inhibition
Homo sapiens
XMP
5 mM, 41% inhibition
Homo sapiens
XTP
5 mM, 44% inhibition
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
effect of AMP on kinetic parameters
Homo sapiens
0.48
-
5-phospho-alpha-D-ribose 1-diphosphate
in Tris buffer
Homo sapiens
0.65
-
Mg2+
-
Homo sapiens
1
4.5
L-glutamine
-
Homo sapiens
1.6
-
L-glutamine
-
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
little or no activity in mitochondria or microsomes
Homo sapiens
5829
-
soluble
-
Homo sapiens
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
activation, approx. 15% as effective as Mg2+ or Mn2+
Homo sapiens
Co2+
activation, approx. 40% as effective as Mg2+ or Mn2+
Homo sapiens
Mg2+
Km-value: 0.65 mM, inhibition above 10 mM; required
Homo sapiens
Mn2+
required, equally effective as Mg2+
Homo sapiens
additional information
not activated by Ba2+, Cd2+, Cu2+, Fe2+, Hg2+, Ni2+, Zn2+
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
Homo sapiens
regulating enzyme of purine biosynthesis
L-glutamate + 5-phospho-beta-D-ribosylamine + diphosphate
-
Homo sapiens
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Commentary
Organism
partial
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
placenta
-
Homo sapiens
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.0055
-
-
Homo sapiens
Storage Stability
Storage Stability
Organism
4°C, 50 mM phosphate bufer, pH 7.4, 5 mM MgCl2, 60 mM 2-mercaptoethanol, at least 4 weeks, no loss of activity
Homo sapiens
4°C, partially purified preparation in 50 mM phosphate buffer, pH 7.4, 5 mM Mg2+ and 60 mM 2-mercaptoethanol, at least 4 weeks
Homo sapiens
4°C, phosphate buffer, 10 d, 40% loss of activity
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
-
489757
Homo sapiens
5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate
-
489757
Homo sapiens
-
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
regulating enzyme of purine biosynthesis
489757
Homo sapiens
L-glutamate + 5-phospho-beta-D-ribosylamine + diphosphate
-
489757
Homo sapiens
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6
8
broad, phosphate buffer
Homo sapiens
6.5
-
imidazole/HCl buffer
Homo sapiens
7.5
-
Tris/HCl buffer
Homo sapiens
General Stability (protein specific)
General Stability
Organism
Mg2+ and phosphate are essential for stability
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
6-iodopurine
5 mM, 39% inhibition
Homo sapiens
6-mercaptopurine ribonucleotide
5 mM, 64% inhibition
Homo sapiens
ADP
5 mM, 40% inhibition
Homo sapiens
allopurinol ribonucleotide
5 mM, 68% inhibition
Homo sapiens
AMP
5 mM, 76% inhibition, noncompetive vs. glutamine
Homo sapiens
ATP
5 mM, 21% inhibition
Homo sapiens
CMP
5 mM, 22% inhibition
Homo sapiens
dCMP
5 mM, 26% inhibition
Homo sapiens
GDP
5 mM, 40% inhibition
Homo sapiens
GMP
0.5 mM; 5 mM, 70% inhibition
Homo sapiens
GTP
5 mM, 13% inhibition
Homo sapiens
IDP
5 mM, 29% inhibition
Homo sapiens
IMP
5 mM, 41% inhibition
Homo sapiens
methyl-dCMP
5 mM, 47% inhibition
Homo sapiens
OMP
5 mM, 25% inhibition
Homo sapiens
phosphate
competitive vs. 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
TMP
5 mM, 42% inhibition
Homo sapiens
TTP
5 mM, 12% inhibition
Homo sapiens
UDP
5 mM, 19% inhibition
Homo sapiens
UMP
5 mM, 25% inhibition
Homo sapiens
UTP
5 mM, 16% inhibition
Homo sapiens
XDP
5 mM, 27% inhibition
Homo sapiens
XMP
5 mM, 41% inhibition
Homo sapiens
XTP
5 mM, 44% inhibition
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
effect of AMP on kinetic parameters
Homo sapiens
0.48
-
5-phospho-alpha-D-ribose 1-diphosphate
in Tris buffer
Homo sapiens
0.65
-
Mg2+
-
Homo sapiens
1
4.5
L-glutamine
-
Homo sapiens
1.6
-
L-glutamine
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
little or no activity in mitochondria or microsomes
Homo sapiens
5829
-
soluble
-
Homo sapiens
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
activation, approx. 15% as effective as Mg2+ or Mn2+
Homo sapiens
Co2+
activation, approx. 40% as effective as Mg2+ or Mn2+
Homo sapiens
Mg2+
Km-value: 0.65 mM, inhibition above 10 mM; required
Homo sapiens
Mn2+
required, equally effective as Mg2+
Homo sapiens
additional information
not activated by Ba2+, Cd2+, Cu2+, Fe2+, Hg2+, Ni2+, Zn2+
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
Homo sapiens
regulating enzyme of purine biosynthesis
L-glutamate + 5-phospho-beta-D-ribosylamine + diphosphate
-
Homo sapiens
?
Purification (Commentary) (protein specific)
Commentary
Organism
partial
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
placenta
-
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.0055
-
-
Homo sapiens
Storage Stability (protein specific)
Storage Stability
Organism
4°C, 50 mM phosphate bufer, pH 7.4, 5 mM MgCl2, 60 mM 2-mercaptoethanol, at least 4 weeks, no loss of activity
Homo sapiens
4°C, partially purified preparation in 50 mM phosphate buffer, pH 7.4, 5 mM Mg2+ and 60 mM 2-mercaptoethanol, at least 4 weeks
Homo sapiens
4°C, phosphate buffer, 10 d, 40% loss of activity
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
-
489757
Homo sapiens
5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate
-
489757
Homo sapiens
-
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
regulating enzyme of purine biosynthesis
489757
Homo sapiens
L-glutamate + 5-phospho-beta-D-ribosylamine + diphosphate
-
489757
Homo sapiens
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6
8
broad, phosphate buffer
Homo sapiens
6.5
-
imidazole/HCl buffer
Homo sapiens
7.5
-
Tris/HCl buffer
Homo sapiens
Other publictions for EC 2.4.2.14
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736969
Coleto
Functional specialization of o ...
Phaseolus vulgaris
Plant Cell Environ.
39
1767-1779
2016
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1
1
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4
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1
1
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1
1
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736921
Goswami
Role and regulation of coordin ...
Homo sapiens
Oncotarget
6
23445-23461
2015
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1
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1
1
1
1
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736283
Batool
In silico analysis of the amid ...
Homo sapiens
Invest. New Drugs
31
1355-1363
2013
-
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6
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1
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3
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4
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1
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1
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722319
Qin
Phosphoribosylamidotransferase ...
Paraphaeosphaeria minitans, Paraphaeosphaeria minitans ZS-1
Fungal Genet. Biol.
48
956-965
2011
-
-
1
-
-
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5
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1
1
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702270
Wang
Computational studies of ammon ...
Escherichia coli
Biochemistry
48
12272-12282
2009
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1
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2
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1
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693634
Patrick
A study in molecular contingen ...
Escherichia coli K-12
J. Mol. Biol.
377
323-336
2008
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1
1
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2
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1
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1
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3
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1
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1
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1
1
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2
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1
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693004
Koenigsknecht
Glutamine phosphoribosylpyroph ...
no activity in Escherichia coli, no activity in Escherichia coli DM1293, no activity in Salmonella sp.
J. Biol. Chem.
282
28379-28384
2007
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3
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694707
Walsh
Chemical genetic identificatio ...
Arabidopsis thaliana
Plant Physiol.
144
1292-1304
2007
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-
1
1
1
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4
1
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1
2
-
6
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1
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5
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1
1
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3
5
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1
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5
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680467
Browne
PurF-independent phosphoribosy ...
Salmonella enterica
J. Bacteriol.
188
6786-6792
2006
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1
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1
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657611
Jimenez
Metabolic engineering of the p ...
Eremothecium gossypii
Appl. Environ. Microbiol.
71
5743-5751
2005
-
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1
-
4
-
2
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1
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1
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1
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1
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1
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1
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489773
Yamaoka
Feedback inhibition of amidoph ...
Homo sapiens
J. Biol. Chem.
276
21285-21291
2001
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1
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1
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5
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3
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3
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489772
Bera
Temperature-dependent function ...
Aquifex aeolicus
J. Bacteriol.
182
3734-3739
2000
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1
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4
2
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4
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1
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4
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1
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489771
Kian
Purine biosynthesis de novo in ...
Bos taurus
Biochemistry
64
648-651
1999
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2
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1
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1
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489770
Muchmore
Crystal structure of glutamine ...
Bacillus subtilis, Escherichia coli
Protein Sci.
7
39-51
1998
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2
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3
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489768
Schoettle
Mechanisms of inhibition of am ...
Mus musculus
Biochemistry
36
6377-6383
1997
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2
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1
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2
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2
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Reynoldds
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Wong
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Kinetic, physical, and regulat ...
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Messenger
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Affinity chromatography of Bac ...
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Itoh
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