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Literature summary for 2.4.2.12 extracted from
- Targeting metabolic reprogramming in metastatic melanoma The key role of nicotinamide phosphoribosyltransferase (NAMPT) (2020), Semin. Cell Dev. Biol., 98, 192-201 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme is a therapeutic target in metastatic melanoma | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| FK866 | specific inhibitor | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nicotinamide D-ribonucleotide + diphosphate | Homo sapiens | - |
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P43490 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| melanoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nicotinamide D-ribonucleotide + diphosphate | - |
Homo sapiens | nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| eNAMPT | extracellular enzyme | Homo sapiens |
| iNAMPT | intracellular enzyme | Homo sapiens |
| Nampt | - |
Homo sapiens |
| PBEF | - |
Homo sapiens |
| pre-B colony enhancing factor | - |
Homo sapiens |
| Visfatin | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the enzyme is often overexpressed in tumor tissues, including in breast, gastric, pancreatic, colorectal, ovarian, prostate, thyroid and endometrial carcinomas as well as in brain tumors, sarcoma, melanoma and hematological malignancies | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the up-regulation of enzyme in cancer affects cell growth and survival, immune responses and inflammation, signaling, redox reactions and metabolic pathways, DNA repair and epigenetic regulation of gene expression, and invasiveness properties of tumor | Homo sapiens |
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Release 2023.1 (January 2023)
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