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Literature summary for 2.4.2.12 extracted from

  • Elliott, G.C.; Rechsteiner, M.C.
    Evidence for a physiologically active nicotinamide phosphoribosyltransferase in cultured human fibroblasts (1982), Biochem. Biophys. Res. Commun., 104, 996-1002.
    View publication on PubMed

General Stability

General Stability Organism
freeze-thawing inactivates Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information nicotinic acid, thymine, 5-bromouracil Homo sapiens
NAD+
-
Homo sapiens
nicotinate adenine dinucleotide not inhibitory Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0016
-
nicotinamide
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast diploid, GM 1362, from patient with Lesch-Nyhan disease Homo sapiens
-

Storage Stability

Storage Stability Organism
-80°C, crude, 4-6 months Homo sapiens
4°C, crude, inactivation overnight Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
?
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate specific for nicotinamide, no substrates: thymine, 5-bromouracil, nicotinic acid adenine dinucleotide Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP requirement Homo sapiens