Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
expressed in Escherichia coli | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[(4-nitrophenyl)methyl]pyrrolidin-1-ium | - |
Homo sapiens | |
(1R,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[(4-nitrophenyl)methyl]pyrrolidin-1-ium | - |
Plasmodium falciparum | |
(1S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[2-(4-nitrophenyl)ethyl]pyrrolidin-1-ium | - |
Homo sapiens | |
(1S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[2-(4-nitrophenyl)ethyl]pyrrolidin-1-ium | - |
Plasmodium falciparum | |
(2R,3R,4S)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium | - |
Homo sapiens | |
(2R,3R,4S)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium | - |
Plasmodium falciparum | |
(2R,3R,4S)-1-[2-(6-carboxy-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium | - |
Homo sapiens | |
(2R,3R,4S)-1-[2-(6-carboxy-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium | - |
Plasmodium falciparum | |
(2R,3S)-3-hydroxy-2-(hydroxymethyl)-5-(4-nitrophenyl)pyrrolidin-1-ium | - |
Homo sapiens | |
(2R,3S)-3-hydroxy-2-(hydroxymethyl)-5-(4-nitrophenyl)pyrrolidin-1-ium | - |
Plasmodium falciparum | |
(2S,3S,4R,5R)-2-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium | - |
Homo sapiens | |
(2S,3S,4R,5R)-2-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium | - |
Plasmodium falciparum | |
(2S,3S,4R,5R)-2-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium | - |
Homo sapiens | |
(2S,3S,4R,5R)-2-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium | - |
Plasmodium falciparum | |
(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium | - |
Homo sapiens | |
(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium | - |
Plasmodium falciparum | |
(3R,4R)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium | - |
Homo sapiens | |
(3R,4R)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium | - |
Plasmodium falciparum | |
(7R,8R,9S,9aS)-8,9-dihydroxy-7-(hydroxymethyl)-8,9,9a,10-tetrahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidine-1,3,5(2H)-trione | - |
Homo sapiens | |
(7R,8R,9S,9aS)-8,9-dihydroxy-7-(hydroxymethyl)-8,9,9a,10-tetrahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidine-1,3,5(2H)-trione | - |
Plasmodium falciparum | |
1,3-dihydroxy-N-[(4-nitrophenyl)methyl]propan-2-aminium | - |
Homo sapiens | |
1,3-dihydroxy-N-[(4-nitrophenyl)methyl]propan-2-aminium | - |
Plasmodium falciparum | |
1,3-dihydroxy-N-[2-(4-nitrophenyl)ethyl]propan-2-aminium | - |
Homo sapiens | |
1,3-dihydroxy-N-[2-(4-nitrophenyl)ethyl]propan-2-aminium | - |
Plasmodium falciparum | |
1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]pyrrolidin-1-ium | - |
Homo sapiens | |
1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]pyrrolidin-1-ium | - |
Plasmodium falciparum | |
4-nitrophenyl beta-D-ribose | - |
Homo sapiens | |
4-nitrophenyl beta-D-ribose | - |
Plasmodium falciparum | |
4-nitrophenyl beta-D-ribose 5'-phosphate | - |
Homo sapiens | |
4-nitrophenyl beta-D-ribose 5'-phosphate | - |
Plasmodium falciparum | |
[(2R,3R,4S,5S)-5-(4-carboxypyridin-3-yl)-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate | - |
Homo sapiens | |
[(2R,3R,4S,5S)-5-(4-carboxypyridin-3-yl)-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate | - |
Plasmodium falciparum | |
[(2R,3R,4S,5S)-5-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate | - |
Homo sapiens | |
[(2R,3R,4S,5S)-5-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate | - |
Plasmodium falciparum | |
[(2R,3R,4S,5S)-5-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate | - |
Homo sapiens | |
[(2R,3R,4S,5S)-5-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate | - |
Plasmodium falciparum | |
[(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-4-hydroxypyrrolidin-1-ium-3-yl]methyl hydrogen phosphate | - |
Homo sapiens | |
[(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-4-hydroxypyrrolidin-1-ium-3-yl]methyl hydrogen phosphate | - |
Plasmodium falciparum | |
[(7R,8R,9S,9aS)-8,9-dihydroxy-1,3,5-trioxo-1,2,3,5,8,9,9a,10-octahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidin-7-yl]methyl hydrogen phosphate | - |
Homo sapiens | |
[(7R,8R,9S,9aS)-8,9-dihydroxy-1,3,5-trioxo-1,2,3,5,8,9,9a,10-octahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidin-7-yl]methyl hydrogen phosphate | - |
Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
orotate + 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | - |
orotidine 5'-phosphate + diphosphate | - |
? | |
orotate + 5-phospho-alpha-D-ribose 1-diphosphate | Plasmodium falciparum | - |
orotidine 5'-phosphate + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
orotate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | orotidine 5'-phosphate + diphosphate | - |
? | |
orotate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Plasmodium falciparum | orotidine 5'-phosphate + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
OPRT | - |
Homo sapiens |
OPRT | - |
Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00004 | - |
4-nitrophenyl beta-D-ribose 5'-phosphate | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.000041 | - |
4-nitrophenyl beta-D-ribose 5'-phosphate | at pH 8.0 and 25°C | Homo sapiens | |
0.00012 | - |
4-nitrophenyl beta-D-ribose | at pH 8.0 and 25°C | Homo sapiens | |
0.00019 | - |
4-nitrophenyl beta-D-ribose | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.08 | - |
(2R,3R,4S)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium | at pH 8.0 and 25°C | Homo sapiens | |
0.083 | - |
(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium | at pH 8.0 and 25°C | Homo sapiens | |
0.09 | - |
[(7R,8R,9S,9aS)-8,9-dihydroxy-1,3,5-trioxo-1,2,3,5,8,9,9a,10-octahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidin-7-yl]methyl hydrogen phosphate | at pH 8.0 and 25°C | Homo sapiens | |
0.11 | - |
(7R,8R,9S,9aS)-8,9-dihydroxy-7-(hydroxymethyl)-8,9,9a,10-tetrahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidine-1,3,5(2H)-trione | at pH 8.0 and 25°C | Homo sapiens | |
0.12 | - |
1,3-dihydroxy-N-[2-(4-nitrophenyl)ethyl]propan-2-aminium | at pH 8.0 and 25°C | Homo sapiens | |
0.14 | - |
[(2R,3R,4S,5S)-5-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate | at pH 8.0 and 25°C | Homo sapiens | |
0.15 | - |
1,3-dihydroxy-N-[(4-nitrophenyl)methyl]propan-2-aminium | at pH 8.0 and 25°C | Homo sapiens | |
0.17 | - |
[(7R,8R,9S,9aS)-8,9-dihydroxy-1,3,5-trioxo-1,2,3,5,8,9,9a,10-octahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidin-7-yl]methyl hydrogen phosphate | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.2 | - |
[(2R,3R,4S,5S)-5-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate | at pH 8.0 and 25°C | Homo sapiens | |
0.2 | - |
(1R,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[(4-nitrophenyl)methyl]pyrrolidin-1-ium | at pH 8.0 and 25°C | Homo sapiens | |
0.22 | - |
(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.23 | - |
(2R,3S)-3-hydroxy-2-(hydroxymethyl)-5-(4-nitrophenyl)pyrrolidin-1-ium | at pH 8.0 and 25°C | Homo sapiens | |
0.23 | - |
(1S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[2-(4-nitrophenyl)ethyl]pyrrolidin-1-ium | at pH 8.0 and 25°C | Homo sapiens | |
0.24 | - |
[(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-4-hydroxypyrrolidin-1-ium-3-yl]methyl hydrogen phosphate | at pH 8.0 and 25°C | Homo sapiens | |
0.25 | - |
1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]pyrrolidin-1-ium | at pH 8.0 and 25°C | Homo sapiens | |
0.27 | - |
(7R,8R,9S,9aS)-8,9-dihydroxy-7-(hydroxymethyl)-8,9,9a,10-tetrahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidine-1,3,5(2H)-trione | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.27 | - |
(2R,3R,4S)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.29 | - |
(2R,3R,4S)-1-[2-(6-carboxy-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium | at pH 8.0 and 25°C | Homo sapiens | |
0.3 | - |
(2S,3S,4R,5R)-2-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.35 | - |
(2S,3S,4R,5R)-2-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.35 | - |
[(2R,3R,4S,5S)-5-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.36 | - |
(2S,3S,4R,5R)-2-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium | at pH 8.0 and 25°C | Homo sapiens | |
0.37 | - |
[(2R,3R,4S,5S)-5-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.47 | - |
1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]pyrrolidin-1-ium | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.48 | - |
(2R,3S)-3-hydroxy-2-(hydroxymethyl)-5-(4-nitrophenyl)pyrrolidin-1-ium | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.5 | - |
[(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-4-hydroxypyrrolidin-1-ium-3-yl]methyl hydrogen phosphate | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.5 | - |
1,3-dihydroxy-N-[(4-nitrophenyl)methyl]propan-2-aminium | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.51 | - |
1,3-dihydroxy-N-[2-(4-nitrophenyl)ethyl]propan-2-aminium | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.52 | - |
(3R,4R)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium | at pH 8.0 and 25°C | Homo sapiens | |
0.53 | - |
(2S,3S,4R,5R)-2-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium | at pH 8.0 and 25°C | Homo sapiens | |
0.57 | - |
(1S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[2-(4-nitrophenyl)ethyl]pyrrolidin-1-ium | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.69 | - |
(2R,3R,4S)-1-[2-(6-carboxy-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium | at pH 8.0 and 25°C | Plasmodium falciparum | |
0.75 | - |
(1R,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[(4-nitrophenyl)methyl]pyrrolidin-1-ium | at pH 8.0 and 25°C | Plasmodium falciparum | |
1.3 | - |
(3R,4R)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium | at pH 8.0 and 25°C | Plasmodium falciparum | |
4.3 | - |
[(2R,3R,4S,5S)-5-(4-carboxypyridin-3-yl)-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate | at pH 8.0 and 25°C | Homo sapiens | |
15.5 | - |
[(2R,3R,4S,5S)-5-(4-carboxypyridin-3-yl)-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate | at pH 8.0 and 25°C | Plasmodium falciparum |