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Literature summary for 2.4.2.10 extracted from

  • Hozumi, Y.; Tanaka, T.; Nakano, T.; Matsui, H.; Nasu, T.; Koike, S.; Kakehata, S.; Ito, T.; Goto, K.
    Orotate phosphoribosyltransferase localizes to the Golgi complex and its expression levels affect the sensitivity to anti-cancer drug 5-fluorouracil (2015), Biomed. Res., 36, 403-409.
    View publication on PubMed
Search for more literature for 2.4.2.10

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
orotate + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 orotidine 5'-phosphate + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-Sepharose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens 5-fluorouridine 5'-phosphate + diphosphate
-
 ?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens orotidine 5'-phosphate + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
OPRT
-
 Homo sapiens