Literature summary for 2.4.2.10 extracted from

Ichikawa, W.; Takahashi, T.; Suto, K.; Sasaki, Y.; Hirayama, R.
Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen (2006), Clin. Cancer Res., 12, 3928-3934.

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Protein Variants

Protein Variants	Comment	Organism
G213A	OPRT, the gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen, the Ala allele in the enzyme G213A polymorphism and the two tandem repeats in the TYMS promoter polymorphism are associated with grade 3 to 4 neutropenia and diarrhea, distribution in 69 patients samples, genotyping, relationship between OPRT mRNA expression and the OPRT G213A polymorphism, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate	Homo sapiens	-	5-fluorouridine 5'-phosphate + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colon	mucosa	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate	-	Homo sapiens	5-fluorouridine 5'-phosphate + diphosphate	-	?

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Release 2023.1 (January 2023)