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Literature summary for 2.4.2.10 extracted from

  • Sakurai, Y.; Sakamoto, K.; Sugimoto, Y.; Yoshida, I.; Masui, T.; Tonomura, S.; Inaba, K.; Shoji, M.; Nakamura, Y.; Uyama, I.; Komori, Y.; Ochiai, M.; Matsuura, S.; Tanaka, H.; Oka, T.; Fukushima, M.
    Orotate phosphoribosyltransferase levels measured by a newly established enzyme-linked immunosorbent assay in gastric carcinoma (2006), Cancer Sci., 97, 492-498.
    View publication on PubMed
Search for more literature for 2.4.2.10

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens the enzyme is involved in degradation of 5-fluorouracil being the key enzyme related to the first-step activation process of 5-fluorouracil, and possibly predicts chemosensitivity to 5-fluorouracil, overview 5-fluorouridine 5'-phosphate + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cholangioma cell
-
 Homo sapiens
-
colonic cancer cell
-
 Homo sapiens
-
gastric carcinoma cell
-
 Homo sapiens
-
lung cancer cell
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-
uterine cancer cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 ELISA assay method development and evaluation for enzyme detection and quantification in cancer tissue, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens 5-fluorouridine 5'-phosphate + diphosphate
-
 ?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate the enzyme is involved in degradation of 5-fluorouracil being the key enzyme related to the first-step activation process of 5-fluorouracil, and possibly predicts chemosensitivity to 5-fluorouracil, overview Homo sapiens 5-fluorouridine 5'-phosphate + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
OPRT
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens