Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G51S | the mutant possesses wild type phosphorylase activity levels toward inosine and ribavirin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ganciclovir | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
x * 30000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
His-Talon column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
small intestine | high expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine + phosphate | - |
Homo sapiens | hypoxanthine + alpha-D-ribose 1-phosphate | - |
r | |
ribavirin + phosphate | - |
Homo sapiens | 1,2,4-triazole-3-carboxamide + alpha-D-ribose 1-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 30000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PNP | - |
Homo sapiens |
purine nucleoside phosphorylase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | key enzyme in ribavirin metabolism of the human small intestine | Homo sapiens |