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Literature summary for 2.4.2.1 extracted from

  • Hassan, A.E.; Abou-Elkhair, R.A.; Parker, W.B.; Allan, P.W.; Secrist, J.A.
    6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases (2016), Bioorg. Chem., 65, 9-16.
    View publication on PubMed
Search for more literature for 2.4.2.1

Protein Variants

Protein Variants Comment Organism
M64V the mutant is able to cleave numerous 5'-modified nucleoside analogs with much greater efficiency than the wild type enzyme but no activity with adenosine or inosine Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
purine deoxyribonucleoside + phosphate Escherichia coli
-
 purine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
purine ribonucleoside + phosphate Escherichia coli
-
 purine + alpha-D-ribose 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
9-(6-deoxy-5-C-methyl-beta-D-ribo-hexofuranosyl)-6-methylpurine + phosphate
-
 Escherichia coli ?
-
 r
9-(6-deoxy-beta-D-allofuranosyl)-6-methylpurine + phosphate
-
 Escherichia coli ?
-
 r
9-(beta-D-ribofuranosyl)-6-methylpurine + phosphate
-
 Escherichia coli ?
-
 r
9-[2-deoxy-beta-D-ribofuranosyl]-6-methylpurine + phosphate
-
 Escherichia coli ?
-
 r
9-[beta-D-arabinofuranosyl]-2-fluoroadenine + phosphate
-
 Escherichia coli ?
-
 r
adenosine + phosphate
-
 Escherichia coli adenine + alpha-D-ribose 1-phosphate
-
 ?
inosine + phosphate
-
 Escherichia coli hypoxanthine + alpha-D-ribose 1-phosphate
-
 r
purine deoxyribonucleoside + phosphate
-
 Escherichia coli purine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
purine ribonucleoside + phosphate
-
 Escherichia coli purine + alpha-D-ribose 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PNP
-
 Escherichia coli
purine nucleoside phosphorylase
-
 Escherichia coli