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Literature summary for 2.4.2.1 extracted from

  • Zang, Y.; Wang, W.H.; Wu, S.W.; Ealick, S.E.; Wang, C.C.
    Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex (2005), J. Biol. Chem., 280, 22318-22325.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
structures of the enzyme complexed with 2-fluoro-2'-deoxyadenosine, formycin A, adenosine, inosine or 2'-deoxyinosine determined at resolutions ranging from 2.4 to 2.9 A Trichomonas vaginalis

Inhibitors

Inhibitors Comment Organism Structure
2-fluoro-2'-deoxyadenosine the substrate releases highly cytotoxic 2-fluoroadenine. 2-Fluoro-2'-deoxyadenosine and 2-fluoroadenine exert strong inhibition of Trichomonas vaginalis growth with estimated IC50 values of 106 nM and 84 nM. 2-Fluoro-2'-deoxyadenosine might be useful as a potential chemotherapeutic agent against Trichomonas vaginalis Trichomonas vaginalis

Organism

Organism UniProt Comment Textmining
Trichomonas vaginalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-fluoro-2-deoxyadenosine + phosphate
-
 Trichomonas vaginalis adenine + 2-fluoro-2-deoxy-alpha-D-ribose 1-phosphate the product 2-fluoroadenine is highly cytotoxic for Trichomonas vaginalis ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000106 0.000084 the substrate releases highly cytotoxic 2-fluoroadenine. 2-Fluoro-2'-deoxyadenosine and 2-fluoroadenine exert strong inhibition of Trichomonas vaginalis growth with estimated IC50 values of 106 nM and 84 nM. 2-Fluoro-2'-deoxyadenosine might be useful as a Trichomonas vaginalis 2-fluoro-2'-deoxyadenosine