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Literature summary for 2.4.2.1 extracted from

  • Bzowska, A.; Kulikowska, E.; Shugar, D.
    Formycins A and B and some analogues: selective inhibitors of bacterial (Escherichia coli) purine nucleoside phosphorylase (1992), Biochim. Biophys. Acta, 1120, 239-247.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
6-methylformycin
-
 Escherichia coli
Formycin A
-
 Escherichia coli
formycin B
-
 Escherichia coli
N(1)-Methylformycin A
-
 Escherichia coli
N(6)-Methylformycin A competitive with respect to inosine, 7-methylguanosine and 7-methyladenosine Escherichia coli
N(6)-methylformycin B
-
 Escherichia coli
oxoformycin A weak Escherichia coli
oxoformycin B weak Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-methyladenosine + phosphate
-
 Escherichia coli 7-methyladenine + alpha-D-ribose 1-phosphate
-
 ?
7-methylguanosine + phosphate
-
 Escherichia coli 7-methylguanine + alpha-D-ribose 1-phosphate
-
 ?
inosine + phosphate
-
 Escherichia coli hypoxanthine + alpha-D-ribose 1-phosphate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0003
-
 N(6)-methyl-formycin A pH 7 Escherichia coli
0.0046
-
 formycin B pH 7 Escherichia coli
0.0053
-
 Formycin A
-
 Escherichia coli
0.018
-
 N(6)-methylformycin B pH 7 Escherichia coli
0.027
-
 N(1)-Methylformycin A pH 7 Escherichia coli
0.18
-
 oxoformycin B pH 7 Escherichia coli
0.2
-
 oxoformycin A pH 7 Escherichia coli