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Literature summary for 2.4.1.92 extracted from

  • Pohlentz, G.; Klein, D.; Schwarzmann, G.; Schmitz, D.; Sandhoff, K.
    Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver (1988), Proc. Natl. Acad. Sci. USA, 85, 7044-7048 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.92

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ganglioside GD3 competitive inhibition of GM2 synthesis Rattus norvegicus
ganglioside GM3 competitive inhibition of GD2 synthesis Rattus norvegicus
additional information no inhibition by ganglioside GQ1b Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.152
-
 ganglioside GD3 pH 7.35, 37°C Rattus norvegicus
0.385
-
 ganglioside GM3 pH 7.35, 37°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi vesicle
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q10468
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + ganglioside GD3 ganglioside GD3 i.e. 1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->8)-O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide Rattus norvegicus UDP + ganglioside GD2
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 ganglioside GM3 i.e. 1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide Rattus norvegicus UDP + ganglioside GM2
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + lactosylceramide
-
 Rattus norvegicus UDP-N-acetyl-alpha-D-galactosamine + ganglioside GA2
-
 ?

Synonyms

Synonyms Comment Organism
GA2 synthase
-
 Rattus norvegicus
GD2 synthase
-
 Rattus norvegicus
GM2 synthase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.35
-
 assay at Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.066
-
 ganglioside GD3 inhibition of GM2 synthesis, pH 7.35, 37°C Rattus norvegicus
0.12
-
 ganglioside GM3 inhibition of GD2 synthesis, pH 7.35, 37°C Rattus norvegicus