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Literature summary for 2.4.1.92 extracted from

  • Klein, D.; Pohlentz, G.; Schwarzmann, G.; Sandhoff, K.
    Substrate specificity of GM2 and GD3 synthase of Golgi vesicles derived from rat liver (1987), Eur. J. Biochem., 167, 417-424 .
    View publication on PubMed
Search for more literature for 2.4.1.92

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylglycerol stimulates the activity of GM2 synthase without disrupting the vesicular intactness Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Rattus norvegicus 5794
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q10468
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 ganglioside GM3 i.e. 1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramideganglioside Rattus norvegicus UDP + ganglioside GM2
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 amide 10% of the activity with ganglioside GM3 Rattus norvegicus UDP + ganglioside GM2 amide
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 methyl ester 13% of the activity with ganglioside GM3 Rattus norvegicus UDP + ganglioside GM2 methyl ester
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 methylamide 1% of the activity with ganglioside GM3 Rattus norvegicus UDP + ganglioside GM2 methylamide
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + ganglioside lyso-GM3 28% of the activity with ganglioside GM3 Rattus norvegicus UDP + ganglioside lyso-GM2
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + ganglioside N-acetyl-lyso-GM3 160% of the activity with ganglioside GM3 Rattus norvegicus UDP + ganglioside N-acetyl-lyso-GM2
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + ganglioside N-octanoyl-lyso-GM3 122% of the activity with ganglioside GM3 Rattus norvegicus UDP + ganglioside N-octanoyl-lyso-GM2
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + ganglioside N1-pyrenyl-dodecanoyl-lyso-GM3 102% of the activity with ganglioside GM3 Rattus norvegicus UDP + ganglioside N1-pyrenyl-dodecanoyl-lyso-GM2
-
 ?

Synonyms

Synonyms Comment Organism
GM2 synthase
-
 Rattus norvegicus
UDP-2-acetamido-2-deoxy-D-galactose:(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine acetamidodeoxygalactosyl-transferase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.35
-
 assay at Rattus norvegicus