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Literature summary for 2.4.1.92 extracted from

  • Ramakrishnan, B.; Qasba, P.K.
    Role of a single amino acid in the evolution of glycans of invertebrates and vertebrates (2007), J. Mol. Biol., 365, 570-576.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
I285Y site-directed mutagenesis, mutation of the residue to the human analogue results in change of substrate specificity from a beta4GalNAc-T1 to a beta4Gal-T1 by reducing its N-acetylgalactosaminyltransferase activity by nearly 1000fold, fold, while enhancing its galactosyltransferase activity by 80fold, overview Drosophila melanogaster
Y285I site-directed mutagenesis, mutation of the residue to the Drosophila melanogaster analogue results in change of substrate specificity from a beta4Gal-T1 to a beta4GalNAc-T1, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Drosophila melanogaster during evolution, beta4Gal-T1 appears as a result of the single amino acid substitution of Tyr or Phe for Leu or Ile in the invertebrate beta4GalNAc-T1, overview ?
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?
additional information Homo sapiens during evolution, beta4Gal-T1 appears as a result of the single amino acid substitution of Tyr or Phe for Leu or Ile in the invertebrate beta4GalNAc-T1, overview ?
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?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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-
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Homo sapiens
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-
-

Reaction

Reaction Comment Organism Reaction ID
UDP-N-acetyl-alpha-D-galactosamine + O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide = UDP + O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-[N-acetyl-alpha-neuraminyl-(2->3)]-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide residue 285 determines the donor substrate specificity of the enzyme, catalytic binding pocket structure, overview Drosophila melanogaster
UDP-N-acetyl-alpha-D-galactosamine + O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide = UDP + O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-[N-acetyl-alpha-neuraminyl-(2->3)]-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide residue 285 determines the donor substrate specificity of the enzyme, catalytic binding pocket structure, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information during evolution, beta4Gal-T1 appears as a result of the single amino acid substitution of Tyr or Phe for Leu or Ile in the invertebrate beta4GalNAc-T1, overview Drosophila melanogaster ?
-
?
additional information during evolution, beta4Gal-T1 appears as a result of the single amino acid substitution of Tyr or Phe for Leu or Ile in the invertebrate beta4GalNAc-T1, overview Homo sapiens ?
-
?
additional information the wild-type Drosophila beta4GalNAc-T1 enzyme binds to the mammary gland-specific protein alpha-lactalbumin Drosophila melanogaster ?
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?

Synonyms

Synonyms Comment Organism
beta1,4-N-acetylgalactosaminyltransferase
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Drosophila melanogaster
beta1,4-N-acetylgalactosaminyltransferase
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Homo sapiens
beta4GalNAc-T1
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Drosophila melanogaster
beta4GalNAc-T1
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Homo sapiens