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Literature summary for 2.4.1.92 extracted from
- Biosynthesis of monosulfogangliotriaosylceramide and GM2 by N-acetylgalactosaminyltransferase from rat brain (1987), J. Biochem., 101, 1115-1127.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Heptylthioglucoside | activation | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.026 | - |
UDP-N-acetyl-D-galactosamine | cosubstrate GM3 | Rattus norvegicus | |
| 0.082 | - |
UDP-N-acetyl-D-galactosamine | cosubstrate SM3 | Rattus norvegicus | |
| 0.19 | - |
GM3 | - |
Rattus norvegicus | |
| 2.1 | - |
GM3(N-acetylneuraminic acid) | - |
Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | not | Rattus norvegicus | |
| Mg2+ | not | Rattus norvegicus | |
| Mn2+ | - |
Rattus norvegicus | |
| additional information | no activation by Zn2+ | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -80°C, several months, crude Triton X-100 extract | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no substrates are SM4-ganglioside, Gb3- and Gb4-ceramide | Rattus norvegicus | ? | - |
? | |
| UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide | - |
Rattus norvegicus | UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide | i.e. GM2(N-acetylneuraminic acid)-ganglioside | ? | |
| UDP-N-acetyl-D-galactosamine + SM3-ganglioside | best substrate, no substrates are SM4-ganglioside, Gb3- and Gb4-ceramide | Rattus norvegicus | UDP + SM2-ganglioside | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 7.5 | - |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.2 | 8.5 | about half-maximal activity at pH 6.2 and about 85% of maximal activity at pH 8.5 | Rattus norvegicus |
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