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Literature summary for 2.4.1.87 extracted from

  • Milland, J.; Christiansen, D.; Lazarus, B.D.; Taylor, S.G.; Xing, P.X.; Sandrin, M.S.
    The molecular basis for galalpha(1,3)gal expression in animals with a deletion of the alpha1,3galactosyltransferase gene (2006), J. Immunol., 176, 2448-2454.
    View publication on PubMed
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Application

Application Comment Organism
medicine Galalpha(1,3)Gal synthesized by iGb3S is immunogenic and elicits antibodies in GGTA1-/- mice. Galalpha(1,3)Gal synthesized by iGb3S may affect survival of pig transplants in humans Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus iGb3S is an additional enzyme capable of synthesizing the xenoreactive Galalpha(1,3)Gal epitope. Galalpha(1,3)Gal synthesized by iGb3S, in contrast to alpha1,3GT, is resistant to downregulation by competition with alpha1,2fucosyltransferase. Galalpha(1,3)Gal synthesized by iGb3S is immunogenic and elicits antibodies in GGTA1-/- mice. Galalpha(1,3)Gal synthesized by iGb3S may affect survival of pig transplants in humans ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information iGb3S is an additional enzyme capable of synthesizing the xenoreactive Galalpha(1,3)Gal epitope. Galalpha(1,3)Gal synthesized by iGb3S, in contrast to alpha1,3GT, is resistant to downregulation by competition with alpha1,2fucosyltransferase. Galalpha(1,3)Gal synthesized by iGb3S is immunogenic and elicits antibodies in GGTA1-/- mice. Galalpha(1,3)Gal synthesized by iGb3S may affect survival of pig transplants in humans Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
iGb3S
-
 Mus musculus