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Literature summary for 2.4.1.87 extracted from

  • Hellrung, D.J.; Kisselev, S.; Link, C.J.
    Co-expression of alpha(1,3)galactosyltransferase and Bacillus thuringiensis PIPLC enhances hyperacute rejection of tumor cells (2007), Cancer Immunol. Immunother., 56, 25-34.
    View publication on PubMed

Application

Application Comment Organism
medicine the Bacillus thuringiensis phosphatidylinositol-specific phospholipase C and the alpha(1,3)GT genes are engineered to be delivered to cells in two separate retroviral vectors. Activity of phosphatidylinositol-specific phospholipase C, secreted from transduced A549 human lung tumor cells shows a synergistic increase in alphagal mediated complement killing in an in vitro assay. When applied to in vivo therapy of solid tumors, this approach may enhance anti-tumor immune responses Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
murine alpha(1,3)GT gene is cloned into the Moloney murine leukemia retroviral vector, pLNCX, giving rise to pLNCKG expression in A549 human lung tumor cells Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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