BRENDA - Enzyme Database
show all sequences of 2.4.1.87

Roles of individual enzyme-substrate interactions by alpha-1,3-galactosyltransferase in catalysis and specificity

Zhang, Y.; Swaminathan, G.J.; Deshpande, A.; Boix, E.; Natesh, R.; Xie, Z.; Acharya, K.R.; Brew, K.; Biochemistry 42, 13512-13521 (2003)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
catalytic domain (residues 80-386) is expressed in Escherichia coli
Bos taurus
Crystallization (Commentary)
Crystallization
Organism
vapor diffusion hanging drop method
Bos taurus
Engineering
Amino acid exchange
Commentary
Organism
E317Q
turnover number for transferase reaction is approximately 2400times lower than that of the wild-type enzyme 120fold reduction in hydrolysis of UDP-galactose. Km-value for UDP-galactose is unchanged
Bos taurus
H280Q
80fold reduction in catalytic activity
Bos taurus
Q247E
50fold reduction in turnover number for transferase reaction, unchanged hydrolase activity, Km-values for UDP-galactose and lactose are similar to the wild-type values
Bos taurus
R365K
mutation reduces turnover-number for UDP-galactose hydrolysis about 10fold but has no significant effect on the affinity for UDP-galactose
Bos taurus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00069
-
UDP-galactose
37°C, mutant enzyme E317Q, hydrolase reaction
Bos taurus
0.01
-
UDP-galactose
37°C, mutant enzyme R365K, hydrolase reaction
Bos taurus
0.1
-
UDP-galactose
37°C, wild-type enzyme, hydrolase reaction
Bos taurus
0.13
-
UDP-galactose
37°C, mutant enzyme E317Q, galactosyltransferase reaction
Bos taurus
0.15
-
UDP-galactose
37°C, mutant enzyme Q247E, hydrolase reaction
Bos taurus
0.43
-
UDP-galactose
37°C, wild-type enzyme, galactosyltransferase reaction
Bos taurus
0.66
-
UDP-galactose
37°C, mutant enzyme Q247E, galactosyltransferase reaction
Bos taurus
0.72
-
UDP-galactose
37°C, mutant enzyme R365K, galactosyltransferase reaction
Bos taurus
1.02
-
UDP-galactose
37°C, mutant enzyme H280Q, galactosyltransferase reaction
Bos taurus
12.8
-
lactose
37°C, mutant enzyme R365K, galactosyltransferase reaction
Bos taurus
19.9
-
lactose
37°C, wild-type enzyme, galactosyltransferase reaction
Bos taurus
20.2
-
lactose
37°C, mutant enzyme Q247E, galactosyltransferase reaction
Bos taurus
33.6
-
lactose
37°C, mutant enzyme H280Q, galactosyltransferase reaction
Bos taurus
233
-
lactose
37°C, mutant enzyme E317Q, galactosyltransferase reaction
Bos taurus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
P14769
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
UDP-galactose + H2O
-
657968
Bos taurus
UDP + D-galactose
-
-
-
?
UDP-galactose + lactose
-
657968
Bos taurus
UDP + alpha-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-glucose
-
-
-
?
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.00013
-
UDP-galactose
37°C, mutant enzyme E317Q, hydrolase reaction
Bos taurus
0.0014
-
UDP-galactose
37°C, mutant enzyme R365K, hydrolase reaction
Bos taurus
0.011
-
UDP-galactose
37°C, mutant enzyme Q247E, hydrolase reaction
Bos taurus
0.016
-
UDP-galactose
37°C, wild-type enzyme, hydrolase reaction
Bos taurus
0.14
-
lactose
37°C, mutant enzyme Q247E, galactosyltransferase reaction
Bos taurus
0.14
-
UDP-galactose
37°C, mutant enzyme Q247E, galactosyltransferase reaction
Bos taurus
0.17
-
lactose
37°C, mutant enzyme R365K, galactosyltransferase reaction
Bos taurus
0.17
-
UDP-galactose
37°C, mutant enzyme R365K, galactosyltransferase reaction
Bos taurus
0.77
-
lactose
37°C, mutant enzyme H280Q, galactosyltransferase reaction
Bos taurus
0.77
-
UDP-galactose
37°C, mutant enzyme H280Q, galactosyltransferase reaction
Bos taurus
6.4
-
lactose
37°C, wild-type enzyme, galactosyltransferase reaction
Bos taurus
6.4
-
UDP-galactose
37°C, wild-type enzyme, galactosyltransferase reaction
Bos taurus
Cloned(Commentary) (protein specific)
Commentary
Organism
catalytic domain (residues 80-386) is expressed in Escherichia coli
Bos taurus
Crystallization (Commentary) (protein specific)
Crystallization
Organism
vapor diffusion hanging drop method
Bos taurus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
E317Q
turnover number for transferase reaction is approximately 2400times lower than that of the wild-type enzyme 120fold reduction in hydrolysis of UDP-galactose. Km-value for UDP-galactose is unchanged
Bos taurus
H280Q
80fold reduction in catalytic activity
Bos taurus
Q247E
50fold reduction in turnover number for transferase reaction, unchanged hydrolase activity, Km-values for UDP-galactose and lactose are similar to the wild-type values
Bos taurus
R365K
mutation reduces turnover-number for UDP-galactose hydrolysis about 10fold but has no significant effect on the affinity for UDP-galactose
Bos taurus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00069
-
UDP-galactose
37°C, mutant enzyme E317Q, hydrolase reaction
Bos taurus
0.01
-
UDP-galactose
37°C, mutant enzyme R365K, hydrolase reaction
Bos taurus
0.1
-
UDP-galactose
37°C, wild-type enzyme, hydrolase reaction
Bos taurus
0.13
-
UDP-galactose
37°C, mutant enzyme E317Q, galactosyltransferase reaction
Bos taurus
0.15
-
UDP-galactose
37°C, mutant enzyme Q247E, hydrolase reaction
Bos taurus
0.43
-
UDP-galactose
37°C, wild-type enzyme, galactosyltransferase reaction
Bos taurus
0.66
-
UDP-galactose
37°C, mutant enzyme Q247E, galactosyltransferase reaction
Bos taurus
0.72
-
UDP-galactose
37°C, mutant enzyme R365K, galactosyltransferase reaction
Bos taurus
1.02
-
UDP-galactose
37°C, mutant enzyme H280Q, galactosyltransferase reaction
Bos taurus
12.8
-
lactose
37°C, mutant enzyme R365K, galactosyltransferase reaction
Bos taurus
19.9
-
lactose
37°C, wild-type enzyme, galactosyltransferase reaction
Bos taurus
20.2
-
lactose
37°C, mutant enzyme Q247E, galactosyltransferase reaction
Bos taurus
33.6
-
lactose
37°C, mutant enzyme H280Q, galactosyltransferase reaction
Bos taurus
233
-
lactose
37°C, mutant enzyme E317Q, galactosyltransferase reaction
Bos taurus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
UDP-galactose + H2O
-
657968
Bos taurus
UDP + D-galactose
-
-
-
?
UDP-galactose + lactose
-
657968
Bos taurus
UDP + alpha-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-glucose
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.00013
-
UDP-galactose
37°C, mutant enzyme E317Q, hydrolase reaction
Bos taurus
0.0014
-
UDP-galactose
37°C, mutant enzyme R365K, hydrolase reaction
Bos taurus
0.011
-
UDP-galactose
37°C, mutant enzyme Q247E, hydrolase reaction
Bos taurus
0.016
-
UDP-galactose
37°C, wild-type enzyme, hydrolase reaction
Bos taurus
0.14
-
lactose
37°C, mutant enzyme Q247E, galactosyltransferase reaction
Bos taurus
0.14
-
UDP-galactose
37°C, mutant enzyme Q247E, galactosyltransferase reaction
Bos taurus
0.17
-
lactose
37°C, mutant enzyme R365K, galactosyltransferase reaction
Bos taurus
0.17
-
UDP-galactose
37°C, mutant enzyme R365K, galactosyltransferase reaction
Bos taurus
0.77
-
lactose
37°C, mutant enzyme H280Q, galactosyltransferase reaction
Bos taurus
0.77
-
UDP-galactose
37°C, mutant enzyme H280Q, galactosyltransferase reaction
Bos taurus
6.4
-
lactose
37°C, wild-type enzyme, galactosyltransferase reaction
Bos taurus
6.4
-
UDP-galactose
37°C, wild-type enzyme, galactosyltransferase reaction
Bos taurus
Other publictions for EC 2.4.1.87
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736317
Ardevol
Reaction mechanisms in carbohy ...
Bos taurus, Micrococcus luteus
J. Am. Chem. Soc.
137
7528-7547
2015
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
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2
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2
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2
-
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-
-
-
-
-
-
-
-
4
4
-
-
-
736808
Park
Comparative n-linked glycan an ...
Sus scrofa
Mol. Cells
38
65-74
2015
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
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-
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1
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1
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1
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1
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1
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1
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-
-
-
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-
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2
2
-
-
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736656
Galili
Significance of the evolutiona ...
Ateles sp., Callithrix jacchus, Cercopithecoidea, Chlorocebus sabaeus, Erythrocebus patas, Eutheria, Gorilla gorilla, Hominoidea, Homo sapiens, Lemuridae, Macaca mulatta, Metatheria, Pan troglodytes, Platyrrhini, Pongo abelii, Pongo pygmaeus, Saimiri sp.
J. Mol. Evol.
80
1-9
2014
-
-
11
-
-
-
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-
-
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-
7
-
17
-
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7
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11
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7
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-
7
-
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-
-
-
-
-
-
-
-
17
17
-
-
-
736308
Gomez
Substrate-assisted and nucleop ...
Bos taurus
J. Am. Chem. Soc.
135
7053-7063
2013
-
-
-
-
1
-
-
-
-
-
-
-
-
1
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-
-
-
-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
721667
Han
The wciN gene encodes an alpha ...
Streptococcus pneumoniae
Biochemistry
51
5804-5810
2012
-
-
1
-
6
-
-
-
-
1
2
-
-
1
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
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-
-
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-
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1
-
-
6
-
-
-
-
-
-
1
2
-
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
722792
Ohashi
Identification of novel alpha1 ...
Schizosaccharomyces pombe, Schizosaccharomyces pombe ARC039
J. Biol. Chem.
287
38866-38875
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
4
-
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-
-
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-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707367
Jamaluddin
Crystal structure of alpha-1,3 ...
Bos taurus
Biochem. Biophys. Res. Commun.
385
601-604
2009
-
1
-
1
1
-
-
4
-
1
-
1
-
1
-
-
1
-
-
-
-
-
5
-
-
-
-
4
-
-
-
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-
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-
-
1
-
-
1
1
-
-
-
-
4
-
1
-
1
-
-
-
1
-
-
-
-
5
-
-
-
-
4
-
-
-
-
-
1
1
-
4
4
707599
Pasek
Bioconjugation and detection o ...
Bos taurus
Bioconjug. Chem.
20
608-618
2009
-
1
1
-
9
-
-
20
-
1
-
1
-
3
-
-
-
-
-
-
2
-
6
-
-
-
-
5
-
-
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-
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-
1
1
-
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9
-
-
-
-
20
-
1
-
1
-
-
-
-
-
-
2
-
6
-
-
-
-
5
-
-
-
-
-
-
-
-
10
10
690994
Tumbale
Structural basis of UDP-galact ...
Bos taurus
Biochemistry
47
8711-8718
2008
-
-
-
1
9
-
-
1
-
1
-
-
-
3
-
-
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-
-
1
-
-
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-
2
12
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693460
Saethre
Cytokine secretion depends on ...
Sus scrofa
J. Immunol.
180
6346-6353
2008
-
-
-
-
1
-
-
-
-
-
-
-
-
5
-
-
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1
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-
-
708604
Tumbale
Screening a limited structure- ...
Bos taurus
Glycobiology
18
1036-1043
2008
-
1
1
1
8
1
-
12
-
1
-
1
-
2
-
-
1
-
-
-
-
-
5
-
-
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-
6
-
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1
1
-
1
8
1
-
-
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12
-
1
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1
-
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1
-
-
-
-
5
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
708606
Shoemaker
Temperature-dependent cooperat ...
Homo sapiens
Glycobiology
18
587-592
2008
-
-
1
-
-
-
-
-
-
1
1
1
-
1
-
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1
-
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1
1
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1
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1
1
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1
1
1
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1
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1
1
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-
-
-
-
-
-
-
-
-
-
672885
Hellrung
Co-expression of alpha(1,3)gal ...
Mus musculus
Cancer Immunol. Immunother.
56
25-34
2007
-
1
1
-
-
-
-
-
-
-
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1
-
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1
1
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-
-
-
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675442
Jamaluddin
Conformational changes induced ...
Bos taurus
J. Mol. Biol.
369
1270-1281
2007
-
-
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1
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-
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1
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1
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-
-
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-
-
-
-
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-
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676897
Koike
Functionally important glycosy ...
Alouatta caraya, Lemur catta, Loris tardigradus
Proc. Natl. Acad. Sci. USA
104
559-564
2007
-
-
-
-
-
-
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8
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691043
Molina
Site-directed mutagenesis of g ...
Bos taurus
Biochim. Biophys. Acta
1770
1266-1273
2007
-
-
1
-
4
-
-
2
-
1
-
-
-
2
-
-
-
1
-
-
1
-
1
-
1
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1
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1
-
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4
-
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2
-
1
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-
1
-
1
-
1
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1
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675197
Milland
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489477
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Stults
Characterization of the substr ...
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Glycobiology
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Henion
Defining the minimal size of c ...
Callithrix jacchus, no activity in african green monkey
Glycobiology
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Glycosyltransferase activities ...
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Identification and characteriz ...
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Van Halbeek
alpha-D-Galactosyltransferase ...
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Novikoff ascites tumor cells c ...
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An alpha-D-galactosyltransfera ...
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Glycosyltransferases and their ...
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Basu
Enzymatic synthesis of a blood ...
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