BRENDA - Enzyme Database
show all sequences of 2.4.1.87

Regulation of alpha1,3galactosyltransferase expression in pig endothelial cells: Implications for xenotransplantation

Mercier, D.; Charreau, B.; Wierinckx, A.; Keijser, R.; Adriaensens, L.; Van den Berg, R.; Joziasse, D.H.; Eur. J. Biochem. 269, 1464-1473 (2002)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in COS-7 cells, promotor sequences A-C determination and analysis, gene regulation and regulatory sequences, alternative splicing
Sus scrofa
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Sus scrofa
the alphaGal(1-3)Gal epitope is the major xenoantigen responsible for the hyperacute vascular rejection occurring in pig-to-primate organ transplantation
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Sus scrofa
AF415202
; TNFalpha inducible
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
aorta
-
Sus scrofa
-
endothelium
primary and permanent, aortic
Sus scrofa
-
kidney
-
Sus scrofa
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
the alphaGal(1-3)Gal epitope is the major xenoantigen responsible for the hyperacute vascular rejection occurring in pig-to-primate organ transplantation
489479
Sus scrofa
?
-
-
-
-
UDP-galactose + saccharides containing Galalpha(1-3)Gal epitope
-
489479
Sus scrofa
?
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in COS-7 cells, promotor sequences A-C determination and analysis, gene regulation and regulatory sequences, alternative splicing
Sus scrofa
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Sus scrofa
the alphaGal(1-3)Gal epitope is the major xenoantigen responsible for the hyperacute vascular rejection occurring in pig-to-primate organ transplantation
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
aorta
-
Sus scrofa
-
endothelium
primary and permanent, aortic
Sus scrofa
-
kidney
-
Sus scrofa
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
the alphaGal(1-3)Gal epitope is the major xenoantigen responsible for the hyperacute vascular rejection occurring in pig-to-primate organ transplantation
489479
Sus scrofa
?
-
-
-
-
UDP-galactose + saccharides containing Galalpha(1-3)Gal epitope
-
489479
Sus scrofa
?
-
-
-
?
Other publictions for EC 2.4.1.87
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736317
Ardevol
Reaction mechanisms in carbohy ...
Bos taurus, Micrococcus luteus
J. Am. Chem. Soc.
137
7528-7547
2015
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4
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736808
Park
Comparative n-linked glycan an ...
Sus scrofa
Mol. Cells
38
65-74
2015
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736656
Galili
Significance of the evolutiona ...
Ateles sp., Callithrix jacchus, Cercopithecoidea, Chlorocebus sabaeus, Erythrocebus patas, Eutheria, Gorilla gorilla, Hominoidea, Homo sapiens, Lemuridae, Macaca mulatta, Metatheria, Pan troglodytes, Platyrrhini, Pongo abelii, Pongo pygmaeus, Saimiri sp.
J. Mol. Evol.
80
1-9
2014
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11
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17
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7
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17
17
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736308
Gomez
Substrate-assisted and nucleop ...
Bos taurus
J. Am. Chem. Soc.
135
7053-7063
2013
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2
2
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721667
Han
The wciN gene encodes an alpha ...
Streptococcus pneumoniae
Biochemistry
51
5804-5810
2012
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6
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1
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722792
Ohashi
Identification of novel alpha1 ...
Schizosaccharomyces pombe, Schizosaccharomyces pombe ARC039
J. Biol. Chem.
287
38866-38875
2012
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1
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707367
Jamaluddin
Crystal structure of alpha-1,3 ...
Bos taurus
Biochem. Biophys. Res. Commun.
385
601-604
2009
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1
1
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4
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4
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1
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4
4
707599
Pasek
Bioconjugation and detection o ...
Bos taurus
Bioconjug. Chem.
20
608-618
2009
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1
1
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9
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20
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1
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1
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3
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6
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9
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20
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2
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6
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5
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10
10
690994
Tumbale
Structural basis of UDP-galact ...
Bos taurus
Biochemistry
47
8711-8718
2008
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1
9
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1
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1
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3
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1
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2
12
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1
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1
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693460
Saethre
Cytokine secretion depends on ...
Sus scrofa
J. Immunol.
180
6346-6353
2008
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1
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5
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708604
Tumbale
Screening a limited structure- ...
Bos taurus
Glycobiology
18
1036-1043
2008
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1
1
1
8
1
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12
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1
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2
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1
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5
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6
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708606
Shoemaker
Temperature-dependent cooperat ...
Homo sapiens
Glycobiology
18
587-592
2008
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1
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1
1
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1
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672885
Hellrung
Co-expression of alpha(1,3)gal ...
Mus musculus
Cancer Immunol. Immunother.
56
25-34
2007
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1
1
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1
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675442
Jamaluddin
Conformational changes induced ...
Bos taurus
J. Mol. Biol.
369
1270-1281
2007
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1
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1
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676897
Koike
Functionally important glycosy ...
Alouatta caraya, Lemur catta, Loris tardigradus
Proc. Natl. Acad. Sci. USA
104
559-564
2007
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691043
Molina
Site-directed mutagenesis of g ...
Bos taurus
Biochim. Biophys. Acta
1770
1266-1273
2007
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1
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4
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2
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1
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2
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675197
Milland
The molecular basis for galalp ...
Mus musculus
J. Immunol.
176
2448-2454
2006
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1
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8
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672883
Deriy
In vivo targeting of vaccinati ...
Mus musculus
Cancer Gene Ther.
12
528-539
2005
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1
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658845
Zhang
Roles of active site tryptopha ...
Bos taurus
Glycobiology
14
1295-1302
2004
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1
1
5
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657968
Zhang
Roles of individual enzyme-sub ...
Bos taurus
Biochemistry
42
13512-13521
2003
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1
1
4
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14
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2
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2
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12
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14
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2
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658837
Taylor
Characterization of the rat al ...
Rattus norvegicus
Glycobiology
13
327-337
2003
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489479
Mercier
Regulation of alpha1,3galactos ...
Sus scrofa
Eur. J. Biochem.
269
1464-1473
2002
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1
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489477
Imberty
Fold recognition study of alph ...
Sus scrofa
Glycobiology
9
713-722
1999
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489478
Stults
Characterization of the substr ...
Mus musculus
Glycobiology
9
661-668
1999
1
1
1
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4
1
1
4
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2
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1
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2
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1
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1
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2
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1
1
1
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4
2
1
1
4
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1
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489475
Seppo
Enzymic synthesis of octadecam ...
Bos taurus, Mus musculus
Biochemistry
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1995
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489474
Henion
Defining the minimal size of c ...
Callithrix jacchus, no activity in african green monkey
Glycobiology
4
193-201
1994
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489476
Meldgaard
Blood group ABO-related glycos ...
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54
2440-2447
1994
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489469
Joziasse
Murine alpha 1,3-galactosyltra ...
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267
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1992
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489468
Elices
Biosynthesis of bi-, tri-, and ...
Mus musculus
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1989
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489470
Joziasse
Bovine alpha 1,3-galactosyltra ...
Bos taurus
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264
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1989
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1
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489465
Elices
Glycosyltransferase activities ...
Bos taurus, Mus musculus
Arch. Biochem. Biophys.
254
329-341
1987
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3
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4
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489471
Elices
Purification and characterizat ...
Mus musculus
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1986
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10
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2
10
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489466
Blanken
Biosynthesis of terminal Gal a ...
Bos taurus
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260
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1985
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489464
Van den Eijnden
Identification and characteriz ...
Bos taurus
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134
523-530
1983
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7
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489472
Van Halbeek
alpha-D-Galactosyltransferase ...
Bos taurus
Biochem. Biophys. Res. Commun.
110
124-131
1983
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489473
Van den Eijnden
Novikoff ascites tumor cells c ...
Rattus norvegicus
J. Biol. Chem.
258
3435-3437
1983
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489463
Blake
An alpha-D-galactosyltransfera ...
Mus musculus
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256
5387-5393
1981
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6
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489467
Beyer
Glycosyltransferases and their ...
Bos taurus
Adv. Enzymol. Relat. Areas Mol. Biol.
52
23-175
1981
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489462
Basu
Enzymatic synthesis of a blood ...
Oryctolagus cuniculus
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248
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1973
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