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Literature summary for 2.4.1.83 extracted from

  • Lamani, E.; Mewbourne, R.B.; Fletcher, D.S.; Maltsev, S.D.; Danilov, L.L.; Veselovsky, V.V.; Lozanova, A.V.; Grigorieva, N.Y.; Pinsker, O.A.; Xing, J.; Forsee, W.T.; Cheung, H.C.; Schutzbach, J.S.; Shibaev, V.N.; Jedrzejas, M.J.
    Structural studies and mechanism of Saccharomyces cerevisiae dolichyl-phosphate-mannose synthase: insights into the initial step of synthesis of dolichyl-phosphate-linked oligosaccharide chains in membranes of endoplasmic reticulum (2006), Glycobiology, 16, 666-678.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information KM-values for synthetic dolichyl phosphate analogs Saccharomyces cerevisiae
0.0246
-
(6Z,10Z,14Z,18Z,22E,26E)-3,7,11,15,19,23,27-heptamethyl-30-(naphthalen-1-ylamino)triaconta-6,10,14,18,22,26-hexaen-1-yl dihydrogen phosphate pH 7.5 Saccharomyces cerevisiae
0.0248
-
(6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39-decamethyl-42-(naphthalen-1-ylamino)dotetraconta-6,10,14,18,22,26,30,34,38-nonaen-1-yl dihydrogen phosphate pH 7.5 Saccharomyces cerevisiae
0.0751
-
(6Z,10E,14E,18E,22E)-3,7,15,19,23,27-hexamethyl-11-[(naphthalen-1-ylamino)methyl]octacosa-6,10,14,18,22,26-hexaen-1-yl dihydrogen phosphate pH 7.5 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane Saccharomyces cerevisiae 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP-mannose + dolichyl phosphate Saccharomyces cerevisiae the enzyme transfers mannose from the water soluble cytoplasmic donor GDP-Man, to the membrane bound, extremely hydrophobic, and long-chain polyisoprenoid acceptor, dolichyl-phosphate GDP + dolichyl D-mannosyl phosphate
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
recombinant
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6Z,10E,14E,18E,22E)-3,7,15,19,23,27-hexamethyl-11-[(naphthalen-1-ylamino)methyl]octacosa-6,10,14,18,22,26-hexaen-1-yl dihydrogen phosphate + dolichyl phosphate
-
Saccharomyces cerevisiae ?
-
?
(6Z,10Z,14Z,18Z,22E,26E)-3,7,11,15,19,23,27-heptamethyl-30-(naphthalen-1-ylamino)triaconta-6,10,14,18,22,26-hexaen-1-yl dihydrogen phosphate + dolichyl phosphate
-
Saccharomyces cerevisiae ?
-
?
(6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39-decamethyl-42-(naphthalen-1-ylamino)dotetraconta-6,10,14,18,22,26,30,34,38-nonaen-1-yl dihydrogen phosphate + dolichyl phosphate
-
Saccharomyces cerevisiae ?
-
?
GDP-mannose + dolichyl phosphate the enzyme transfers mannose from the water soluble cytoplasmic donor GDP-Man, to the membrane bound, extremely hydrophobic, and long-chain polyisoprenoid acceptor, dolichyl-phosphate Saccharomyces cerevisiae GDP + dolichyl D-mannosyl phosphate
-
?
GDP-mannose + dolichyl phosphate or synthetic analogs of dolichyl phosphate Saccharomyces cerevisiae GDP + dolichyl D-mannosyl phosphate
-
?

Synonyms

Synonyms Comment Organism
Dol-P-Man synthase
-
Saccharomyces cerevisiae
DPM1
-
Saccharomyces cerevisiae