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Literature summary for 2.4.1.83 extracted from
- Dissecting the role of dolichol in cell wall assembly in the yeast mutants impaired in early glycosylation reactions (2007), Yeast, 24, 239-252.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | DPM synthase mutants have an aberrant cell wall composition and ultrastructure. Mutant is oversensitive to Calcofluor white, an agent interacting with the cell wall chitin. Chemical analysis of the cell wall alkali-insoluble fraction indicates an increased amount of chitin and changes in the quantity of beta1,6- and beta1,3-glucan in dpm1-6 mutants. Cell wall defect is suppressed by an increased dolichol availability caused by the RER2 (cis-prenyl transferase-encoding) gene overexpression and subsequent upregulation of DolPPGlcNAc2 synthesis. This is concomitant with an increase in glycosylation and stability of the plasma membrane protein Gas1 and rearrangement of the cell wall components | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dolichol phosphoryl mannose synthase | - |
Saccharomyces cerevisiae |
| DPM | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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