Activating Compound | Comment | Organism | Structure |
---|---|---|---|
c-Fos | activity of glucosylceramide synthase is around 5fold higher in presence of high c-Fos levels, induced by nerve growth factor NGF, addition of c-Fos mRNA ASO, which specifically blocks c-Fos expression abolished the induction of glucosylceramide synthase by NGF | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in PC12 cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0069 | - |
UDP-glucose | in absence of c-Fos | Homo sapiens | |
0.0079 | - |
UDP-glucose | in presence of c-Fos | Homo sapiens | |
0.013 | - |
N-(6-((4-nitrobenz-2-oxa-1,3-diazol-7-yl)amino)caproyl)-O1-D-glucosyl-sphingosine | in absence of c-Fos | Homo sapiens | |
0.02 | - |
N-(6-((4-nitrobenz-2-oxa-1,3-diazol-7-yl)amino)caproyl)-O1-D-glucosyl-sphingosine | in presence of c-Fos | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + N-6-[(7-nitrobenzo-2-oxa-1,3-diazol-4-yl)amino]hexanoyl-4-D-erythro-sphingosine | - |
Homo sapiens | UDP + N-(6-((4-nitrobenz-2-oxa-1,3-diazol-7-yl)amino)caproyl)-O1-D-glucosyl-sphingosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GlcCerS | - |
Homo sapiens |
glucosylceramide synthase | - |
Homo sapiens |