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Literature summary for 2.4.1.80 extracted from
- Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neurons (2008), Brain Res., 1191, 136-147.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | GCS expression is significantly down-regulated in Alzheimer brain | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-threo-2-palmitoylamino-3-pyrrolidino-1-propanol | - |
Homo sapiens |  |
| D-threo-2-palmitoylamino-3-pyrrolidino-1-propanol | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebellar cortex | GCS expression is significantly decreased in cortex of Alzheimer disease patients | Homo sapiens | - |
| granule cell | cerebellar granule cells are treated with GCS inhibitor D-threo-2-palmitoylamino-3-pyrrolidino-1-propanol which induces an increase in log-chain ceramides, loss of viability and dramatic changes in neuron/neurite morphology | Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GCS | - |
Homo sapiens |
| GCS | - |
Rattus norvegicus |
| glucosylceramide synthase | - |
Homo sapiens |
| glucosylceramide synthase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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