Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.80 extracted from

  • Boucheron, C.; Desvergnes, V.; Compain, P.; Martin, O.R.; Lavi, A.; Mackeen, M.; Wormald, M.; Dwek, R.; Butters, T.D.
    Design and synthesis of imino-sugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease (2005), Tetrahedron, 16, 1747-1756.
No PubMed abstract available
Search for more literature for 2.4.1.80

Inhibitors

Inhibitors Comment Organism Structure
(1R)-1-C-octyl-N-octyl-1,5-dideoxy-1,5-imino-D-glucitol
-
 Homo sapiens
(1R)-N-butyl-1-C-butyl-1,5-dideoxy-1,5-imino-D-glucitol
-
 Homo sapiens
N-butyl 1-deoxynojirimycin
-
 Homo sapiens
N-butyl-2,4-di-O-butyl-1,5-dideoxy-1,5-imino-D-glucitol 1 mM, 29% inhibition Homo sapiens
N-octyl-2-O-octyl-1,5-dideoxy-1,5-imino-D-glucitol
-
 Homo sapiens
N-octyl-4-O-octyl-1,5-dideoxy-1,5-imino-D-glucitol
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
glucosylceramide synthase
-
 Homo sapiens
UDP-glucose:ceramide glucosyltransferase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.134
-
-
 Homo sapiens N-octyl-4-O-octyl-1,5-dideoxy-1,5-imino-D-glucitol
0.164
-
-
 Homo sapiens N-octyl-2-O-octyl-1,5-dideoxy-1,5-imino-D-glucitol
0.174
-
-
 Homo sapiens (1R)-1-C-octyl-N-octyl-1,5-dideoxy-1,5-imino-Dglucitol
0.609
-
-
 Homo sapiens (1R)-N-butyl-1-C-butyl-1,5-dideoxy-1,5-imino-D-glucitol