Literature summary for 2.4.1.80 extracted from

Jennemann, R.; Sandhoff, R.; Wang, S.; Kiss, E.; Gretz, N.; Zuliani, C.; Martin-Villalba, A.; Jaeger, R.; Schorle, H.; Kenzelmann, M.; Bonrouhi, M.; Wiegandt, H.; Groene, H.J.
Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth (2005), Proc. Natl. Acad. Sci. USA, 102, 12459-12464.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-glucose + N-acylsphingosine	Mus musculus	the enzyme catalyzes the initial step of glycosphingolipid biosynthesis	UDP + D-glucosyl-N-acylsphingosine	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-glucose + N-acylsphingosine	the enzyme catalyzes the initial step of glycosphingolipid biosynthesis	Mus musculus	UDP + D-glucosyl-N-acylsphingosine	-	?
UDP-glucose + N-acylsphingosine	Ugcg-deficient mice die between postnatal day 11 and postnatal day 24. Glycosphingolipids are required for brain maturation after birth	Mus musculus	UDP + D-glucosyl-N-acylsphingosine	-	?

Synonyms

Synonyms	Comment	Organism
UDP-glucose:ceramide glucosyltransferase	-	Mus musculus
Ugcg	-	Mus musculus

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Release 2023.1 (January 2023)