Literature summary for 2.4.1.80 extracted from

Jennemann, R.; Sandhoff, R.; Langbein, L.; Kaden, S.; Rothermel, U.; Gallala, H.; Sandhoff, K.; Wiegandt, H.; Groene, H.J.
Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis (2007), J. Biol. Chem., 282, 3083-3094.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-glucose + N-acylsphingosine	Mus musculus	the transient formation of glucosylceramide is vital for a regular arrangement of lipids and proteins in lamellar bodies and for the maintenance of the epidermal barrier	UDP + D-glucosyl-N-acylsphingosine	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-glucose + N-acylsphingosine	the transient formation of glucosylceramide is vital for a regular arrangement of lipids and proteins in lamellar bodies and for the maintenance of the epidermal barrier	Mus musculus	UDP + D-glucosyl-N-acylsphingosine	-	?

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Release 2023.1 (January 2023)