Cloned (Comment) | Organism |
---|---|
expression of enzyme gene in antisense orientation, two-hybrid system: coexpression with the reticulon RTN family, interaction especially with RTN-1C | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | antisense expression inhibits enzyme activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(D-threo)-1-phenyl-2-decanoylamino-3-morpholino-1-propanol | specific inhibitor | Homo sapiens | |
additional information | enzyme inhibition by antisense expression | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme decreases apoptosis and induces multidrug resistance, functional interaction with RTN-1C modulates enzyme activity and regulates chemotherapeutic-induced apoptosis in neuroepithelioma cells | ? | - |
? | |
UDP-glucose + N-acylsphingosine | Homo sapiens | key step in biosynthesis of glycosphingolipids | UDP + D-glucosyl-N-acylsphingosine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroepithelioma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme decreases apoptosis and induces multidrug resistance, functional interaction with RTN-1C modulates enzyme activity and regulates chemotherapeutic-induced apoptosis in neuroepithelioma cells | Homo sapiens | ? | - |
? | |
UDP-glucose + N-acylsphingosine | - |
Homo sapiens | UDP + D-glucosyl-N-acylsphingosine | - |
? | |
UDP-glucose + N-acylsphingosine | key step in biosynthesis of glycosphingolipids | Homo sapiens | UDP + D-glucosyl-N-acylsphingosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCS | - |
Homo sapiens |
glucosylceramide synthase | - |
Homo sapiens |