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Literature summary for 2.4.1.80 extracted from

  • Di Sano, F.; Fazi, B.; Citro, G.; Lovat, P.E.; Cesareni, G.; Piacentini, M.
    Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells (2003), Cancer Res., 63, 3860-3865.
    View publication on PubMed
Search for more literature for 2.4.1.80

Cloned(Commentary)

Cloned (Comment) Organism
expression of enzyme gene in antisense orientation, two-hybrid system: coexpression with the reticulon RTN family, interaction especially with RTN-1C Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information antisense expression inhibits enzyme activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(D-threo)-1-phenyl-2-decanoylamino-3-morpholino-1-propanol specific inhibitor Homo sapiens
additional information enzyme inhibition by antisense expression Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme decreases apoptosis and induces multidrug resistance, functional interaction with RTN-1C modulates enzyme activity and regulates chemotherapeutic-induced apoptosis in neuroepithelioma cells ?
-
 ?
UDP-glucose + N-acylsphingosine Homo sapiens key step in biosynthesis of glycosphingolipids UDP + D-glucosyl-N-acylsphingosine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuroepithelioma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme decreases apoptosis and induces multidrug resistance, functional interaction with RTN-1C modulates enzyme activity and regulates chemotherapeutic-induced apoptosis in neuroepithelioma cells Homo sapiens ?
-
 ?
UDP-glucose + N-acylsphingosine
-
 Homo sapiens UDP + D-glucosyl-N-acylsphingosine
-
 ?
UDP-glucose + N-acylsphingosine key step in biosynthesis of glycosphingolipids Homo sapiens UDP + D-glucosyl-N-acylsphingosine
-
 ?

Synonyms

Synonyms Comment Organism
GCS
-
 Homo sapiens
glucosylceramide synthase
-
 Homo sapiens