Literature summary for 2.4.1.80 extracted from

Leipelt, M.; Warnecke, D.C.; Hube, B.; Zahringer, U.; Heinz, E.
Characterization of UDP-glucose: ceramide glucosyltransferases from different organisms (2000), Biochem. Soc. Trans., 28, 751-752.

Search for more literature for 2.4.1.80

Cloned(Commentary)

Cloned (Comment)	Organism
cloning of wild-type and construction of knock-out mutant, functional expression in Saccharomyces cerevisiae strain 334, expression of wild-type leads to accumulation of beta-D-glucopyranosyl ceramides, absent in wild-type Saccharomyces cerevisiae, knock-out mutation is not lethal	Candida albicans
functional expression in Saccharomyces cerevisiae strain 334	Komagataella pastoris
functional expression of 1 isozyme in Saccharomyces cerevisiae strain 334	Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-glucose + N-acylsphingosine	Komagataella pastoris	-	UDP + D-glucosyl-N-acylsphingosine	-	?
UDP-glucose + N-acylsphingosine	Caenorhabditis elegans	-	UDP + D-glucosyl-N-acylsphingosine	-	?
UDP-glucose + N-acylsphingosine	Candida albicans	-	UDP + D-glucosyl-N-acylsphingosine	-	?

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	-	several isoforms	-
Candida albicans	-	-	-
Komagataella pastoris	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-glucose + N-acylsphingosine	-	Komagataella pastoris	UDP + D-glucosyl-N-acylsphingosine	-	?
UDP-glucose + N-acylsphingosine	-	Caenorhabditis elegans	UDP + D-glucosyl-N-acylsphingosine	-	?
UDP-glucose + N-acylsphingosine	-	Candida albicans	UDP + D-glucosyl-N-acylsphingosine	-	?
UDP-glucose + N-acylsphingosine	i.e. ceramide	Komagataella pastoris	UDP + D-glucosyl-N-acylsphingosine	i.e. glucosylceramide	?
UDP-glucose + N-acylsphingosine	i.e. ceramide	Caenorhabditis elegans	UDP + D-glucosyl-N-acylsphingosine	i.e. glucosylceramide	?
UDP-glucose + N-acylsphingosine	i.e. ceramide	Candida albicans	UDP + D-glucosyl-N-acylsphingosine	i.e. glucosylceramide	?

Synonyms

Synonyms	Comment	Organism
GlcCer synthase	-	Komagataella pastoris
GlcCer synthase	-	Caenorhabditis elegans
GlcCer synthase	-	Candida albicans

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Release 2023.1 (January 2023)