Any feedback?
Literature summary for 2.4.1.79 extracted from
- Biosynthesis of globoside and Forssman hapten from trihexosylceramide and properties of beta-N-acetyl-galactosaminyltransferase of guinea pig kidney (1974), Biochim. Biophys. Acta, 337, 92-106.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| nonionic detergents | activation, e.g. Triton X-100 or CF-54 | Cavia porcellus | |
| Triton CF-54 | activates | Cavia porcellus |  |
| Triton X100 | activates | Cavia porcellus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | 25 mM, 99% inhibition | Cavia porcellus | |
| GSH | 2 mM, 17% inhibition | Cavia porcellus | |
| NaN3 | 2 mM, 38% inhibition | Cavia porcellus | |
| sodium deoxycholate | - |
Cavia porcellus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.14 | - |
D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide | - |
Cavia porcellus | |
| 0.23 | - |
UDP-N-acetylgalactosamine | - |
Cavia porcellus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Cavia porcellus | - |
- |
| mitochondrion | - |
Cavia porcellus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | 18% as effective as Mn2+ in activation | Cavia porcellus | |
| Mn2+ | required | Cavia porcellus | |
| Mn2+ | optimal concentration: 10 mM | Cavia porcellus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-galactosamine + D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide | Cavia porcellus | enzyme is involved in globoside biosynthesis | UDP + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Cavia porcellus | - |
| kidney | - |
Cavia porcellus | - |
| spleen | - |
Cavia porcellus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-galactosamine + D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide | - |
Cavia porcellus | UDP + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide | globoside and Forssman hapten | ? | |
| UDP-N-acetyl-D-galactosamine + D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide | - |
Cavia porcellus | UDP + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide | i.e. globoside | ? | |
| UDP-N-acetyl-D-galactosamine + D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide | enzyme is involved in globoside biosynthesis | Cavia porcellus | UDP + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide | - |
? | |
| UDP-N-acetyl-D-galactosamine + disialoganglioside GD3 | - |
Cavia porcellus | UDP + ? | - |
? | |
| UDP-N-acetyl-D-galactosamine + hematoside GM3 | equine erythrocyte hematoside | Cavia porcellus | UDP + ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.9 | - |
- |
Cavia porcellus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 8 | about 50% of maximal activity at pH 5.5 and 8.0 | Cavia porcellus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
