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Literature summary for 2.4.1.69 extracted from

  • Kyprianou, P.; Betteridge, A.; Donald, A.S.; Watkins, W.M.
    Purification of the blood group H gene associated alpha-2-L-fucosyltransferase from human plasma (1990), Glycoconj. J., 7, 573-588.
    View publication on PubMed
Search for more literature for 2.4.1.69

Inhibitors

Inhibitors Comment Organism Structure
beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-D-glucose i.e. lacto-N-neotetraose, competitive with respect to lacto-N-biose I Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.5
-
 beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine pH 7.0, 37°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
158000
-
 gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
purification from plasma Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine i.e. lacto-N-biose I, reaction of EC 2.4.1.69 Homo sapiens GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine 82% of the activity with phenyl beta-D-galactopyranoside ?
additional information the enzyme transfers fucose equally well to type I (Galbeta-(1->3)-GIcNAc) and type 2 (Galbeta-(1->4)-GIcNAc) substrates, reaction of EC 2.4.1.344, but type 3 (Galbeta-(1->3)-GalNAc) structures are less efficient acceptors Homo sapiens ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7
-
 Homo sapiens