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Literature summary for 2.4.1.69 extracted from

  • Isozaki, T.; Ruth, J.H.; Amin, M.A.; Campbell, P.L.; Tsou, P.S.; Ha, C.M.; Haines, G.K.; Edhayan, G.; Koch, A.E.
    Fucosyltransferase 1 mediates angiogenesis, cell adhesion and rheumatoid arthritis synovial tissue fibroblast proliferation (2014), Arthritis Res. Ther., 16, R28.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide Homo sapiens
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GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens P19526
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dermal microvascular endothelial cell
-
Homo sapiens
-
rheumatoid arthritis synovial tissue
-
Homo sapiens
-
synovial fibroblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
Homo sapiens GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
?

Synonyms

Synonyms Comment Organism
alpha(1,2)-fucosyltransferase
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Homo sapiens
fucosyltransferase 1
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Homo sapiens
FUT1
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme activity is increased in arthritis synovial tissue up

General Information

General Information Comment Organism
malfunction blocking enzyme expression in arthritis synovial fibroblasts reduces endothelial cell tube formation Homo sapiens
physiological function the enzyme is responsible for synthesis of the H blood group and Lewis y antigens Homo sapiens