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Literature summary for 2.4.1.69 extracted from

  • Hazra, A.; Kraft, P.; Selhub, J.; Giovannucci, E.L.; Thomas, G.; Hoover, R.N.; Chanock, S.J.; Hunter, D.J.
    Common variants of FUT2 are associated with plasma vitamin B12 levels (2008), Nat. Genet., 40, 1160-1162.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.69

Protein Variants

Protein Variants Comment Organism
I129F most frequent nonsense mutation of FUT2 in populations of Asian ancestry Homo sapiens
W143X Nonsense mutation of FUT2 with a allele frequency of 0.46 in populations of European ancestry. Individuals homozygous for the FUT2 nonsecretor genotype appear to be resistant to infection with Norovirus, suggesting that individuals homozygous for nonsecretor status may be unable to mediate host-microbe interactions. Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q10981
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-

Synonyms

Synonyms Comment Organism
fucosyltransferase
-
 Homo sapiens
FUT2
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 Homo sapiens

General Information

General Information Comment Organism
physiological function Women homozygous for the rs492602 G allele had higher B12 levels. This allele is in strong linkage disequilibrium with the FUT2 W143X nonsecretor variant, suggesting a plausible mechanism for altered B12 absorption and plasma levels. Homo sapiens